Substituted bicycloheptanedione derivative and herbicide

ABSTRACT

The present invention is directed to substituted bicycloheptanedion e derivatives represented by a general formula  I!; ##STR1## wherein R represents C 1  -C 4  alkyl, R 1  represents hydrogen, C 1  -C 10  alkyl, C 2  -C 4  alkenyl, C 2  -C 4  alkynyl, aralkyl, C 2  -C 4  haloalkynyl, C 1  -C 4  alkoxy C 1  -C 4  alkyl, C 1  -C 4  haloalkyl, C 2  -C 4  haloalkenyl, etc. and R 2  represents optionally substituted phenyl or optionally substituted pyridyl, the salts thereof and herbicides comprising the same as the active ingredient.

This application is a 371 of PCT/JP95/02249 filed Nov. 07, 1995.

FIELD OF THE INVENTION

The present invention is related to novel bicycloheptanedione derivatives and a herbicide.

BACKGROUND ART

Substituted bicycloheptanedione derivatives similar to the compounds according to the present invention and herbicides comprising such derivative are disclosed in Japanese Patent Laid-opened No. Hei 3-255047.

DISCLOSURE OF THE INVENTION

It is an object of the present invention to provide a herbicide which can be advantageously manufactured in an industrial scale, assures firm herbicidal efficacy with a lower dose and high safeness, and possesses a better selectivity in the herbicidal activity between crops and weeds.

The present invention is directed to substituted bicycloheptanedion e derivatives represented by a general formula I!; ##STR2## wherein R represents C₁ -C₄ alkyl, R¹ represents hydrogen, C₁ -C₁₀ alkyl in either straight or branched chain, C₂ -C₄ alkenyl, aralkyl, C₂ -C₄ haloalkenyl, C₁ -C₄ alkoxy C₁ -C₄ alkyl, C₁ -C₄ haloalkyl, C₂ -C₄ haloalkenyl, hydroxy C₁ -C₄ alkyl, --A--C₃ -C₄ alkyl, --A--C₃ -C₆ cycloalkyl, --A--C(O)r, --A--CH₂ CN or phenyl, A represents a single bond or C₁ -C₄ alkylene, r represents hydrogen, C₁ -C₄ alkyl C₁ -C₄ alkoxy or phenyl,

and R² represents optionally substituted phenyl or optionally substituted pyridyl,

or the salts thereof, herbicides, and intermediates represented by a general formula II!; ##STR3## wherein R and R¹ are as described above and R¹⁰ is C₁ -C₄ alkyl, aralkyl or acetyl.

In the general formula I! described above, as examples of the C₁ -C₁₀ alkyl in either straight or branched chain represented by R¹, methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, t-butyl, pentyl, neopentyl, hexyl, heptyl, octyl, nonyl, decyl and so on can be given.

As examples of the C₂ -C₄ alkenyl, vinyl, allyl, crotyl and the like can be given.

As examples of the C₂ -C₄ alkylnyl, ethynyl, propargyl and the like can be given.

As examples of the aralkyl, benzyl, α-methylbenzyl, α, α-dimethylbenzyl, 2-phenylethyl, of those which benzene ring may be substituted with any of lower alkyls, halogen atoms, lower alkoxy, nitro, etc., and the like can be given.

As examples of the C₂ -C₄ haloalkynyl, iodopropargyl and the like can be given.

As examples of the C₁ -C₄ alkoxy C₁ -C₄ alkyl, methoxymethyl, methoxyethyl, methoxypropyl, methoxyisopropyl, ethoxymethyl, ethoxyethyL, ethoxypropyl, propoxymethyl, propoxyethyl, propoxypropyl, butoxymethyl, butoxyethyl, isopropoxymethyl, isobutoxymethyl, butoxyethyl, t-butoxymethyl, butoxyethyl and the like can be given.

As examples of the C₁ -C₄ haloalkyl, trifluoromethyl, trifluoroethyl, trichloromethyl, pentafluoroethyl, tribromomethyl and the like can be given.

As examples of the C₂ -C₄ haloalkenyl, chlorovinyl, 3-chloroallyl, 3-chloroallyl, 2,3-dichloroallyl, 1-chloroallyl, 3-chlorocrotonyl and the like can be given.

As examples of the hydroxy C₁ -C₄ alkyl, hydroxymethyl, hydroxyethyl, hydroxypropyl, hydroxybutyl, hydroxyisopropyl and the like can be given.

And, A of --A--C₃ -C₆ cycloalkyl, --A--C(O)r and --A--CH₂ CN described above is a single bond or C₁ -C₄ alkylene, such as methylene, ethylene and trimethylene, and wherein r represents hydrogen, C₁ -C₄ alkyl, C₁ -C₄ alkoxy or phenyl. Further, as examples of the C₃ -C₆ cycloalkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and the like can be given.

As example of the substituent to phenyl and pyridyl represented by R² in the general formula I! described above,

an halogen atom, such as fluorine, chlorine, bromine and iodine,

OR⁵ wherein R⁵ is C₁ -C₄ alkyl, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl and t-butyl, C₂ -C₄ alkenyl, such as vinyl, 1-propenyl, 2-propenyl, isopropenyl, 1-butenyl, 2-butenyl and 3-butenyl, C₂ -C₄ alkynyl, such as ethynyl and propargyl, C₁ -C₄ haloalkyl, such as chloromethyl, dichloromethyl, trichloromethyl, difluoromethyl, trifluoromethyl, bromomethyl, dibromomethyl, chloroethyl, fluoroethyl, dichloroethyl, difluoroethyl, trifluoroethyl, tetrafluoromethyl, perfluoroethyl, chloropropyl, fluoropropyl, perfluoropropyl, chloroisopropyl, fluoroisopropyl, perfluoroisopropyl, chlorobutyl, fluorobutyl, perfluorobutyl, chloroisobutyl, fluoroisobutyl, perfluoroisobutyl, chloro-s-butyl, fluoro-s-butyl, perfluoro-s-butyl, chloro-t-butyl, fluoro-t-butyl and perfluoro-t-butyl, C₁ -C₄ haloalkenyl, such as chlorovinyl fluorovinyl, chloroallyl, fluoroallyl, dichloroallyl, difluoroallyl, trichloroallyl, trifluoroallyl, bromoallyl, chloroisopropenyl, fluoroisopropenyl, chlorocrotyl, fluorocrotyl, dichlorocrotyl, difluorocrotyl, trichlorocrotyl and trifluorocrotyl, phenyl, halophenyl, C₁ -C₄ alkoxy-substituted phenyl, phenyl C₁ -C₄ alkyl, halophenyl C₁ -C₄ alkyl, C₁ -C₄ alkoxy-substituted phenyl C₁ -C₄ alkyl, C₁ -C₄ alkylthio C₁ -C₄ alkyl, C₁ -C₄ alkylsulfonyl C₁ -C₄ alkyl, C₁ -C₄ alkoxy C₁ -C₄ alkyl, alkoxy C₁ -C₄ alkoxy C₁ -C₄ alkyl, C₁ -C₄ alkoxycarbonyl C₁ -C₄ alkyl, carboxy C₁ -C₄ alkyl, cyano C₁ -C₄ alkyl, C₁ -C₄ alkylcarbonyl C₁ -C₄ alkyl, C₃ -C6 cycloalkyl C₁ -C₄ alkyl, provided that the cycloalkyl may contain 1 to 2 oxygen atoms,

C₁ -C₅ alkyl in either straight or branched chain, such as methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, t-butyl, pentyl, isoamyl and neopentyl,

C₂ -C₄ alkenyl in either straight or branched chain, such as vinyl, 1-propenyl, 2-propenyl, isopropenyl, 1-butenyl, 2-butenyl and 3-butenyl,

C₂ -C₄ alkynyl, such as ethynyl, propargyl and butynyl,

C₁ -C₄ haloalkyl in either straight or branched chain, such as chloromethyl, dichloromethyl, trichloromethyl, difluoromethyl, trifluoromethyl, bromomethyl, dibromomethyl, chloroethyl, fluroethyl, dichloroethyl, difluoroethyl, trifluoroethyl, tetrafluoroethyl, perfluoroethyl, chloropropyl, fluoropropyl, perfluoropropyl, chloroisopropyl, fluoroisopropyl, perfluoroisopropyl, chlorobutyl, fluorobutyl, perfluorobutyl, chloroisobutyl, fluoroisobutyl, perfluoroisobutyl, chloro-s-butyl, fluoro-s-butyl, perfluoro-s-butyl, chloro-t-butyl, fluoro-t-butyl and perfluoro-t-butyl,

C₁ -C₄ haloalkenyl in either straight or branched chain, such as chlorovinyl, fluorovinyl, chloroallyl, fluoroallyl, dichloroallyl, difluoroallyl, trichloroallyl, trifluoroallyl, bromoallyl, chloroisopropenyl, fluoroisopropenyl, chlorocrotyl, fluorocrotyl, dichlorocrotyl, difluorocrotyl, trichlorocrotyl and trifluorocrotyl,

C₁ -C₄ alkoxy C₁ -C₄ alkyl, such as methoxymethyl, methoxyethyl, methoxypropyl, methoxyisopropyl, methoxybutyl, ethoxymethyl, ethoxyethyl, ethoxypropyl, ethoxyisopropyl, ethoxybutyl, butoxymethyl, butoxyethyl, butoxypropyl, butoxyisopropyl and butoxybutyl,

C₁ -C₄ alkylthio C₁ -C₄ alkyl, such as methylthiomethyl, methylthioethyl, methylthiopropyl, methylthioisopropyl, methylthiobutyl, ethylthiomethyl, ethylthioethyl, ethylthiopropyl, ethylthioisopropyl, ethylthiobutyl, propylthiomethyl, propylthioethyl, propylthiopropyl, propylthioisopropyl, propylthiobutyl, isopropylthiomethyl, isopropylthioethyl, isopropylthiopropyl, isopropylthioisopropyl, isopropylthiobutyl, butylthiomethyl, butylthioethyl, butylthiopropyl, butylthioisopropyl and butylthiobutyl,

C₁ -C₄ alkylsulfonyl C₁ -C₄ alkyl, such as methylsulfonylmethyl, methylsulfonylethyl, methylsulfonylpropyl, methylsulfonylisopropyl, methylsulfonylbutyl, ethylsulfonylmethyl, ethylsulfonylethyl, ethylsulfonylpropyl, ethylsulfonylisopropyl, ethylsulfonylbutyl, propylsulfonylmethyl, propylsulfonylethyl, propylsulforylpropyl, propylsulfonylisopropyl, propylsulfonylbutyl, isopropylsulfonylmethyl, isopropylsulfonylethyl, isopropylsulfonylpropyl, isopropylsulfonylisopropyl, isopropylsulfonylbutyl, butylsulfonylmethyl, butylsulfonylethyl, butylsulfonylpropyl, butylsulfonylisopropyl and butylsulfonylbutyl,

C₁ -C₄ alkylsulfinyl C₁ -C₄ alkyl, such as methylsulfinylmethyl, methylsulfinylethyl, methylsulfinylpropyl, methylsulfinylisopropyl, methylsulfinylbutyl, ethylsulfinylmethyl, ethylsulfinylethyl, ethylsulfinylpropyl, ethylsulfinylisopropyl, ethylsulfinylbutyl, propylsulfinylmethyl, propylsulfinylethyl, propylsulfinylpropyl, propylsulfinylisopropyl, propylsulfinylbutyl, isopropylsulfinylmethyl, isopropylsulfinylethyl, isopropylsulfinylpropyl, isopropylsulfinylisopropyl, isopropylsulfinylbutyl, butylsulfinylmethyl, buthylsulfinylethyl, butylsulfinylpropyl, butylsulfinylisopropyl and butylsulfinylbutyl,

S(O)_(m) R⁶, wherein R⁶ represents C₁ -C₄ alkyl, C₂ -C₄ alkenyl, C₂ -C₄ alkynyl, C₁ -C₄ haloalkyl, C₂ -C₄ haloalkenyl, phenyl, halophenyl, benzyl, halobenzyl, C₁ -C₄ alkylthio C₁ -C₄ alkyl, C₁ -C₄ alkylsulfonyl C₁ -C₄ alkyl, C₁ -C₄ alkoxy C₁ -C₄ alkyl, C₁ -C₄ alkoxy C₁ -C₄ alkoxy C₁ -C₄ alkyl, C₁ -C₄ alkoxycarbonyl C₁ -C₄ alkyl, carboxy C₁ -C₄ alkyl, cyano C₁ -C₄ alkyl or C₁ -C₄ alkylcarbonyl C₁ -C₄ alkyl, and m represents 0, 1 or 2,

nitro, aminosulfonyl, C₁ -C₄ dialkylaminosulfonyl, such as dimethylaminosulfonyl, methylethylaminosulfonyl, methylproplaminosulfonyl, methylisopropylaminosulfonyl, methylbutylaminosulfonyl, methylisobutylaminosulfonyl, methyl-t-butylamincsulfonyl, diethylaminosulfonyl, ethylpropylaminosulfonyl, ethylisopropylaminosulfonyl, ethylbutylaminosulfonyl, ethylisobutylaminosulfonyl, ethyl-s-butylaminosulfonyl, ethyl-t-butylaminosulfonyl, dipropylaminosulfonyl, propylisopropylaminosulfonyl, propylbutylaminosulfonyl, propylisobutylam inosulfonyl, propyl-t-butylaminosulfonyl, diisopropylaminosulfonyl, isopropylbutylaminosulfonyl, isopropylisobutylaminosulfonyl, isopropyl-t-butylaminosulfonyl, dibutylaminosulfonyl, butylisobutylaminosulfonyl, butyl-t-butylaminosulfonyl and di-t-butylaminosulfonyl,

C₁ -C₄ alkoxycarbonyl, such as methoxycarbonyl, ethonycarbonyl, propoxycarbonyl, isopropoxycarbonyl, butoxycarbonyl, isobutoxycarbonyl, s-butoxycarbonyl and t-butoxycarbonyl,

C₁ -C₄ alkylcarbonyl, such as acetyl, propionyl, propylcarbonyl, isopropylcarbonyl, butylcarbonyl, isobutylcarbonyl, s-butylcarbonyl and t-butylcarbonyl,

CONR¹⁴ R¹⁵ wherein R¹⁴ and R¹⁵ are each independently hydrogen or C₁ -C₄ alkyl, carboxyl, hydroxy, cyano, NR⁷ R⁸ wherein R⁷ and R⁸ are each independently hydrogen, C₁ -C₄ alkyl, C₁ -C₄ alkoxy C₁ -C₄ alkyl, C₁ -C₄ alkoxy, C₁ -C₄ alkytcarbonyl, C₁ -C₄ alkoxycarbonyl or C₁ -C₄ alkylsulfonyl, or pyridyloxy optionally substituted with an halogen atom, C₁ -C₄ alkyl or C₁ -C₄ haloalkyl,

and the phenyl may be substituted with from 1 to 5 substituents, whereas the pyridyl may be substituted with from 1 to 4 substituents, which substituents may be the same or different from one another when phenyl and pyridyl are substituted with more than 2 substituents, respectively.

Further, as examples of the group represented by R², 2,4-di-substituted phenyl, 2,3,4-tri-substituted phenyl, 5-substituted-pyridyl-2-yl, 5,6-di-substituted-pyridyl-2-yl, 2,6-di-substituted-pyridyl-3-yl, 4,6-di-substituted-pyridyl-3-yl and the like can be given.

As more preferable examples of groups represented by R², 2,4-dichlorophenyl, 2-nitro-4-chlorophenyl, 2-nitro-4-methanesulfonytphenyl, 2-chloro-4-methanesulfonylphenyl, 2-nitro-4-trifluoromethylphenyl, 2-chloro-4-trifluoromethylphenyl, 2-nitro-4-cyanophenyl, 2-methyl-4-trifluoromethylphenyl, 2-methyl-4-methanesulfonylphenyl, 2-trifluoromethyl-4-chlorophenyl, 2-trifluoromethyl-4-methanesufonyiphenyl, 2,4-bistrifluoromethylphenyl, 2,4-bis-methanesulfonylphenyl, 2,3,4-trichlorophenyl, 2,3-dichloro-4-methanesulfonylmethylpheniyl, 2,3-dichloro-4-trifluoromethylphenyl, 2,3-dimethyl-4-methanesulfonylphenyl, 2,3-dimethyl-4-trifluoromethylphenyl, 2,3-dimethyl-4-chloropnenyl, 2-chloro-3-methyl-4-methanesulfonylphenyl, 2-chloro-3-methoxy-4-methanesulfonylphenyl, 2-chloro-3-difluoromethoxy-4-methanesulfonylphenyl, 2-chloro-3-trifluoromethoxy-4-methanesulfonylphenyl, 2-chloro-3-trifluoromethyl-4-methanesulfonylphenyl, 2,4-dichloro-3-methoxyphenyl, 2-methyl-3-methoxy-4-chlorophenyl, 2-methyl-3-methoxy-4-methanesulfonylphenyl, 2-trifluoromethyl-3-methoxy-4-methainesulfonylphenyl, 2,4-bis-trifluoromethyl-3-methoxyphenyl, 2-trifluoromethyl-3-methyl-4-methanesulfonylphenyl, 2,4-bis-trifluoromethyl-3-methylphenyl, 2-methyl-3-difluoromethoxy-4-chlorophenyl, 2-methyl-3-difluoromethoxy-4-methanesulfonylphenyl, 2,4,6-tris-trifluoromethylphenyl, 2-methyl-3-halo-4-methanesulfonyl, 2-methyl-6-methanesulfonyl-pyridine-3-yl, 2-trifluoromethyl-6-methanesulfonyl-pyridine-3-yl, 2-chloro-6-methanesulfonyl-pyridine-3-yl, and the like can be given.

(Manufacturing of compounds)

The compounds according to the present invention can be manufactured according to a method represented by the following reaction formula.

(Manufacturing method-1) ##STR4##

In the reaction formula described hereinabove, a compound represented by a general formula IVa! and a compound represented by a general formula IVb! can be obtained by allowing a compound represented by II! in an amount of 1 mol, wherein R¹⁰ represents C₁ -C₄ alkyl, aralkyl or acetyl, to a reaction with a compound represented by III! in an amount of 1 mol, wherein Z represents an halogen atom, alkylcarbonyloxy, alkoxycarbonyloxy or benzoyloxy, in the presence of a base in an excess amount, provided that either the compound represented by II! or the compound represented by III! in an excess amount may be used, alternatively.

As the base to be used in the above reaction, alkali metal hydroxides, such as KOH and NaOH, alkali metal carbonates, alkaline earth metal hydroxides, alkaline earth metal carbonates, tri(C₁ -C₆ alkyl)amines, pyridines, sodium phosphate and the like can be given as examples, and as examples of the solvent to be used in the same reaction, water, methylene chloride, chloroform, toluene, ethyl acetate, N, N-dimethylformamide, THF, dimethoxy ethane, acetonitrile and the like can be given.

The mixture prepared for the reaction is continuously stirred at a temperature of from 0° to 50° C. until completion of the reaction. Alternatively, the compounds represented by IVa! and IVb! are obtainable from a reaction in a two-phase system with using a phase-transfer agent, such as a quaternized ammonium salt.

A compound represented by IVa! and a compound represented by IVb! are also obtainable from a reaction of a compound represented by II! and a compound represented by a general formula R² COOH III'!, which is one of the compound represented by III! and in which Z is hydrcgen, in the presence of a condensing agent, such as DCC. As a solvent to be used in the reaction with DCC as described above, methylene chloride, chloroform, benzene, toluene, ethyl acetate, N, N-dimethylformamide, THF, dimethoxy ethane, acetonitrile, etc. can be used. The mixture prepared for the reaction is stirred at a temperature of from -10° to 50° C. until completion of the reaction, and the reacted-product is prepared pursuant to a customary post-reaction procedure.

In the reaction formula described above, the rearrangement reaction to a compound represented by V! is proceeded in the presence of a cyano compound and a mild base. For example, a compound represented by IVa! in an amount of 1 mol and a compound represented by IVb! in an amount of 1 mol are allowed to a reaction in the presence of said base in an amount of from 1 to 4 mol, and more preferably from 1 to 2 mol, and said cyano compound in an amount of from 0.01 to 0.5 mol or more, and more preferably from 0.05 to 0.2 mol.

As the base to be used in the reaction described above, any of the bases given above can be used.

Also, as the cyano compound described above, potassium cyanide, sodium cyanide, acetone cyanohydrin, hydrogen cyanide, a polymer supporting potassium cyanide, etc. can be used. In addition, by using a phase transfer agent, such as crown ether, time required to accomplish the reaction can be shortened.

And temperature appropriate for the reaction described above is in a range lower than 80° C., and more preferably in a range of from 20° to 40° C.

As the solvent to be used in the reaction described above, 1,2-dichloro ethane, toluene, acetonitrile, methylene chloride, ethyl acetate, N,N-dimethylformamide, methylisobutyl ketone, THF, dimethoxy ethane, etc. can be given as the example.

The compound represented by a general formula V! is also obtainable according to a method as described hereinbelow by allowing a compound represented by II! and a compound represented by VIII! to a reaction in the presence of a base, and as well as in the presence of a lewis acid, if necessary.

The base to be used in the method is an alkali metal hydroxide, such as KOH and NaOH, an alkaline earth metal hydroxide, a tri(C₁ -C₆ alkyl)amine, pyridine, sodium carbonate, sodium phosphate or the like. As examples of the appropriate lewis acid, zinc chloride, aluminium trichloride and the like are given. The reaction is proceeded in an organic solvent, such as acetonitrile and methylene chloride, at an appropriate temperature in a range of from -20° C. to a boiling point of said solvent. It is preferable to use a base and zinc chloride, if the use of the latter is appropriate, both in a slightly excess amount to that of the compound represented by II!.

The compound represented by VI! is manufactured by allowing a compound represented by V! to any of a reaction with a hydrohalogenic acid, such as hydrochloric acid and hydrobromic acid, trifluoroacetic acid, boron tribromide or the like, hydrogenolysis, hydrolysis with an alkali and so on, and by allowing the reacted-product subsequently to hydrolysis, if appropriate.

The compound represented by VI! is derived to a compound represented by VII!, wherein Q is a detaching group such as an halogen atom, alkylsulfonyloxy and arylsulfonyloxy, via any reaction of halogenation, alkylsulfonato formation, and arylsulfonato formation, etc. pursuant to a customarily-known method. By allowing the compound represented by VII! to the said reactions for 30 minutes to several ten hours in a solvent and in the presence of a base in an amount more than 1 mol at a temperature of from -20° C. to a boiling point of the solvent used, and more preferably from an ambient temperature to 100° C., a compound represented by I! can be manufactured.

As examples of the base described above, alkali metal hydroxides, such as KOH and NaOH, alkaline earth metal hydroxides, tri(C₁ -C₆ alkyl) amines, pyridine, DBU, t-BuOK, triton B, sodium carbonate, sodium phosphate and the like are given, and as examples of the solvent, water, alcohols, methylene chloride, benzene, toluene, ethyl acetate, N, N-dimethylformamide, THF, dimethoxy ethane, acetonitrile, etc. can be used either alone or mixtures thereof.

The substituted benzoic acid chloride and substituted benzoic acid described above can be manufactured according to a customarily-known method.

Cyclic dione compounds represented by a general formula II! can be manufactured according to a reaction formula as shown hereinbelow.

Manufacturing method of dione compounds ##STR5##

For example, dione compounds represented by a general formula II! in the reaction formula described above can be manufactured by firstly allowing an unsaturated ester compound represented by a general formula IX!, wherein R¹⁰ is as described above and R¹¹ represents C₁ -C₆ alkyl, and a compound represented by a general formula X!, wherein R¹ is as described above, to a reaction in a solvent for 1 to several ten hours at a temperature of from -78° C. to a boiling point of said solvent in the presence of a base and subsequently neutralizing the reacted-product with an acid, such as hydrochloric acid. As the solvent to use in the above reaction, any of alcohols, THF, N, N-dimethylformamide, toluene, etc. can be used, whereas alkali metal alkoxides, sodium hydride, alkyl lithium, lithium diisopropylamide, etc. can be used as the said base.

Similarly, the dione compounds represented by the general formula II! can be also manufactured in a reaction of a compound represented by XI! and a compound represented by XII!, wherein R¹ is as described above and R¹² represents C₁ -C₆ alkyl.

In addition, according to the same method as described above, a dione compound represented by XV! is manufactured in both reactions of a compound represented by IX! and a compound represented by XIII!, wherein R¹ is as described above, and a compound represented by XI! and a compound represented by XIV!, wherein R¹ and R¹² are as described above, and the said dione compound obtained can be further converted to its enol ether form represented by a general formula XVI! in a lower alcohol represented by a formula, R¹³ OH, in the presence of paratoluenesulfonic acid, etc. pursuant to a customarily-known method. Following thereto, by allowing the said enol ether form represented by XVI! to a reaction with an alkylating agent, such as halogenated C₁ -C₄ alkyl and C₁ -C₄ alkylsulfuric acid, in a solvent for several to several ten hours at a temperature of from -78° C. to a boiling point of the solvent in the presence of a base and subsequently treating the reacted-product with an acid, such as hydrochloric acid, a dione compound represented by the general formula II! can be also manufactured.

(Manufacturing method-2) ##STR6##

The compounds according to the present invention represented by a general formula I! is manufactured by allowing a trione compound represented by a general formula XVIII!, wherein a cyclohexane ring being halogenated, to a reaction with an alcohol represented by a general formula, R¹ OH, wherein R¹ is as described above, in a solvent at an appropriate temperature in a range of from -10° C. to a boiling point of the solvent in the presence of a base. As examples of the base used in the above reaction, alkali metal carbonates, such as NaHCO₃ and K₂ CO₃, alkali metal carboxylates, such as sodium acetate, tri(C₁ -C₆)amines, silver salts, such as silver carbonate, silver oxide, phosphates and the like are given, whereas as the solvent used in the same reaction, R¹ OH, methylene chloride, benzene, ethyl acetate, THF, acetonitrile, dimethoxy ethane, formamide, etc. can be used either alone or in a form of the mixture thereof. The halogenated trione compound represented by XVIII! used in this reaction can be manufactured according to the method described hereinbelow. ##STR7##

Alternatively, the halogenated trione compound represented by a general formula XVIII! can be manufactured by allowing a trione compound represented by a general formula XIX! prepared according to a publicly-known method to a reaction with an halogenating agent, such as phenyltrimethyl ammonium tribromide, bromine and merdoramic acid dibromide, in a solvent for several to several tens hours at a temperature of from 0° C. to a boiling point of the solvent, and more preferably from an ambient temperature to 50° C., and in the presence of either a base or an acid, such as hydrobromic acid, if appropriate. As example of the solvent used in the reaction, methylene chloride, benzene, ethyl acetate, THF, acetonitrile, dimethoxy ethane and the like can be given.

(Manufacturing method-3) ##STR8##

The compounds according to the present invention represented by a general formula I! are also manufactured by allowing a trione compound represented by a general formula XIX!, which is prepared pursuant to a publicly-known method, to a reaction with both an alcohol having a general formula of R¹ OH and an halogenating agent, such as phenyltrimethyl ammonium tribromide, in a solvent for several to several tens hours at an appropriate temperature in a range of from 0° C. to a boiling point of the solvent, and more preferably from an ambient temperature to 50° C. and in the presence of a base. The solvents usable in the reaction are as described above.

All of raw materials represented by a general formulas II!, V!, VI!, VII!, XV!, XVIII!, and XIX! contain several types of optically active substances, respectively, and the compounds according to the present invention represented by a general formula I! also contain their optically active substances, respectively, and such optically active substances further exist in forms of various types of tautomers as represented in the following illustration, respectively. It should be noted that all types of these tautomers are fallen within a scope of the present invention.

Types of tautomers ##STR9##

When the compounds represented by a general formula I! contain a free hydroxy group, respectively, the salts thereof, particularly the salts agriculturally- and horticulturally-acceptable, the enamine form and its analogs, acylates, sulfonates, carbamates, ethers, thio ethers, sulfoxides and sulfones of such compounds can be derived therefrom. As appropriate examples of the salts being agriculturally- and horticulturally-acceptable, sodium salts, potassium salts, calcium salts and ammonium salts of the compounds are given.

As examples of the ammonium salts, salts formed with an ion represented by a general formula, N⁺ R^(a) R^(b) R^(c) R^(d) wherein R^(a), R^(b), R^(c) and R^(d) are each independently hydrogen or any one selected from C₁ -C₁₀ alkyls each substituted with hydroxy or the else when appropriate, can be given. When any of R^(a), R^(b), R^(c) and R^(d) is substituted alkyl, it is preferable that all of R^(a), R^(b), R^(c) and R^(d) contain 1 to 4 carbon atoms therein, respectively.

The appropriate enamine and the analog thereof are defined as a compound in which enol form hydroxy groups (at a part of --OH) are converted to a group represented by a general formula, --N R^(e) R^(f) wherein R^(e) and R^(f) are each independently hydrogen or either alkyl or aryl, for example, phenyl, those which contain 1 to 6 carbon atoms and are substituted depending on the situation, to an halogen atom or to a group represented by a general formula, S(O)_(g) R^(h) wherein R^(h) is either alkyl or aryl, for example, phenyl, which contains 1 to 6 carbon atoms and are substituted depending on the situation, and g represents 0, 1 or 2.

The appropriate acylates, ethers or carbamate derivatives are defined as compounds in which enol form hydroxy groups (at a part of --OH) are converted to any of groups represented by general formulas, --OCOR^(i), --OR^(j) and --OCONR^(k) R^(l) wherein R^(i) and R^(j) are same as R^(h) described above, and R^(k) and R^(l) are same as R^(e) described above. These derivatives can be prepared according to a method customarily-known, and the objective compounds are obtainable after allowing them to an ordinary post-reaction procedure.

Structural formulas of the compounds according to the present invention were determined on the basis of analytical results obtained by using IR, NMR, MS, etc.

BEST MODE FOR CARRYING OUT THE INVENTION

Now, the present invention is further explained in detail with referring to Examples described below.

(EXAMPLE 1)

Manufacturing of 5-ethoxy-3-(3-methoxy-2-methyl-4-methylsulfonylbenzoyl) -5-methylbicyclo 4,1,0!heptane-2,4-dione (cis-form) ##STR10## (1) Manufacturing of 4-ethoxy-5-methoxymethyl-4-methylcyclohexane-1,3-dione ##STR11##

4-ethoxy-5-methoxymethylcyclohexane-1, 3-dione in an amount of 12.0 g (60.0 mmol) was dissolved in methanol in a volume of 150 ml, and sulfuric acid in a catalystic amount was then added to the solution. After stirring the solution for 2 hours, the solvent was removed from the solution by distillation under reduced pressure, and the solution remained was added with diluted hydrochloric acid to adjust it to acidic condition and was then extracted with methylene chloride. The organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, then the solvent was removed by distillation therefrom. The crude product obtained was separated by means of silica gel column chromatography, where a mixture of ethyl acetate and n-hexane at a combining ratio of 1 to 1 is used, to obtain a compound containing both the 1-methyl enol ether form and the 3-methyl enol ether form in total amount of 7.8 g. The yield was 61%, and the physical state of the mixture was liquid having a high viscosity.

The obtained methyl enol ether form in an amount of 7.8 g (36.4 mmol) was dissolved in anhydrous tetrahydrofuran in a volume of 80 ml, and the solution was then fed dropwise slowly with lithium diisopropylamide in an amount of 2.2 equivalents, which consists of 18 ml diisopropylamine, 50 ml n-butyl lithium and 50 ml anhydrous tetrahydrofuran, at -70° C. After stirring the mixture for 30minutes, the mixture was added with iodomethane in a volume of 5.8 ml (93.2 mmol) and was subsequently taken out of a cooling bath and followed by stirring further for 1 hour. The reacted-solution was added with water and diluted hydrochloric acid to adjust it to acidic condition and then extracted with methylene chloride. The organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation. A crude product was separated by means of silica gel column chromatography, where a mixture of ethyl acetate and n-hexane at a combining ratio of 1 to 1 is used, to obtaine a methylated product in an amount of 3.79 g. The yield was 46%, and the product was in liquid state having a high viscosity.

4-ethoxy-1-methoxy-5-methoxymethyl-4-methyl-1-cyclohexene-3-one in an amount of 3.79 g (16.6 mmol) was dissolved in a mixed-solvent consisting of 1,4-dioxane in a volume of 20 ml and diluted hydrochloric acid in a volume of 10 ml, and the solution was then stirred for 15 hours at an ambient temperature. The solvent used was removed by distillation under reduced pressure, then the remained was added with methylene chloride to proceed an extraction. The organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation, thereby affording a viscous liquid product in an amount of 3.55 g. The yield was 99%.

(2) Manufacturing of 4-ethoxy-5-methoxymethyl-2-(3-methoxy-2-methyl-4-methylsulfonylbenzoyl)-4-methylcyclohexane-1,3-dione ##STR12##

4-ethoxy-5-methoxymethyl-4-methylcyclohexane-1, 3-dione in an amount of 3.55 g (16.6 mmol) was dissolved in methylene chloride in a volume of 25 ml, and the solution was allowed to stirring for 5 minutes under cooling with ice following to an addition of triethylamine in an amount of 2.1 g (20.8 mmol). The solution was then further slowly fed dropwise with 25 ml methylene chloride solution of 3-methoxy-2-methyl-4-methylsulfonylbenzoyl chloride in an amount of 4.34 g (16.6 mmol). After stirring the mixture for 1 hour at an ambient temperature, the mixture was then added with both water and diluted hydrochloric acid to extract it, and the organic solvent layer resulted was then washed with an aqueous solution of sodium hydrogencarbonate and subsequently with saturated saline solution, dried with magnesium sulfate, and the solvent remained was removed by distillation. A crude product obtained was dissolved in acetonitrile in a volume of 50 ml, and the solution was then allowed to a reaction for 15 hours at an ambient temperature following to an addition of both triethylamine in an amount of 2.1 g (20.8 mmol) and acetone cyanohydrin in an amount of 0.14 g (1.65 mmol). The solvent used was removed by distillation under reduced pressure, and the residue was dissolved in methylene chloride. The solution was then washed with diluted hydrochloric acid and saturated saline solution in series and dried with magnesium sulfate, and the solvent remained was removed by distillation, affording a substance in an amount of 7.45 g in an amorphous state. The yield was 97%.

(3) Manufacturing of 4-ethoxy-5-hydroxymethyl-2-(3-methoxy-2-methyl-4-methylsulfonylbenzoyl)-4-methylcyclohexane-1,3-dione. ##STR13##

4-ethoxy-5-methoxymethyl-2-(3-methoxy-2-methyl-4-methylsulfonybenzoyl)-4-methylcyclohexane-1,3-dione in an amount of 2.9 g (6.6 mmol) was dissolved in methylene chloride in a volume of 20 ml, and the solution was then fed dropwise with 10 ml methylene chloride solution of boron tribromide in an amount of 1.65 g (6.6 mmol) at 0° C. and was subsequently allowed to stirring for 1 hour at 0° C. Methanol and water both in a small amount were added to the reacted-solution to extract it, and the organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation to obtain a crude product.

The crude product obtained was then purified by means of silica gel column chromatography, where a mixture of chloroform and methanol at a combining ratio of 30 to 1 is used, affording an objective compound in an amount of 1.0 g in an amorphous state. The yield was 36%.

(4) Manufacturing of 5-ethoxy-3-(3-methoxy-2-methyl-4-methylsulfonylbenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione (cis-form). ##STR14##

4-ethoxy-5-hydroxymethyl-2-(3-methoxy-2-methyl-4-methylsullfonylbenzoyl)-4-methylcyclohexane-1,3-dione in an amount of 1.0 g (2.35 mmol) was dissolved in methylene chloride in a volume of 10 ml, and the solution was stirred for 1 hour at 0° C. following to an addition of both triethylamine in an amount of 0.26 g (2.57 mmol) and methanesulfonic acid an hydride in an amount of 0.45 g (2.57 mmol) thereto. The reacted-solution was then added with both water and diluted hydrochloric acid to adjust it to acidic condition for a subsequent extraction with methylene chloride. The organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation, thereby affording a crude product. The obtained crude product in an amount of 0.5 g (0.99 mmol) was then dissolved in benzene in a volume of 5 ml, and the solution was stirred for 2 hours at 60° C. following to an addition of 1,8-diaza-bicyclo 5,4,0!unde-7-cene in a volume of 0.3 ml (1.94 mml). After removing the solvent by distillation under reduced pressure, the reacted-solution was added with both water and diluted hydrochloric acid to adjust it to acidic condition and then extracted with methylene chloride. The organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation. A crude product obtained was then separated by means of thin layer chromatography using silica gel, where a mixture of chloroform and methanol at a combining ration of 20 to 1 is used, to obtain the objective compound in an amount of 0.35 g in an amorphous state. The yield was 86%.

(EXAMPLE 2)

Manufacturing of 3-(3-methoxy-2-methyl-4-methylsulfonylbenzoyl)-5-methyl-(2-propyloxy)bicyclo 4,1,0!heptane-2,4-dione (cis and trans forms). ##STR15##

5-bromo-3-(3-methoxy-2-methyl-4-methylsulfonylbenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione in an amount of 0.88 g (2.0 mmol) was dissolved in a mixture of acetonitrile in a volume of 5 ml and propargyl alcohol in a volume of 5 ml, and the solution was then stirred for 15 hours at an ambient temperature following to an addition of potassium carbonate in an amount of 0.28 g (2.0 mmol). After removing the solvents by distillation under reduced pressure, the solution was then added with both water and diluted hydrochloric acid to adjust it to an acidic condition and was subsequently extracted with methylene chloride. The organic solvent layer resulted was then washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation. A crude product obtained was then separated by means of thin layer chromatography using silica gel, where a mixture of chloroform and methanol at a combining ratio of 30 to 1 is used, affording a trans-form of the objective compound in an amount of 0.26 g and the cis-form in an amount of 0.19 g both in an amorphous state. The yield for the trans-form was 31%, whereas that of the cis-form was 23%.

(Referential Example 1)

Manufacturing of 5-bromo-3-(3-methoxy-2-methyl-4-methylsulforylbenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione. ##STR16##

3-(3-methoxy-2-methyl-4-methytsulfonylbenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione in an amount of 5.00 g was dissolved in methylene chloride in a volume of 50 ml, and the solution was then stirred for 70 hours at an ambient temperature following to an addition of both sodium acetate in an amount of 1.35 g and phenyltrimethyl ammonium bromide (herein after abbreviated as PTAB) in an amount of 5.16 g. After the reaction, the reacted-solution was added with water to extract it with methylene chloride. The organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation. The residue obtained was purified by means of silica get column chromatography to obtain the objective compound in an amount of 1.67 g in pale-yellowish crystalline state. The melting of the compound was in a range of from 155 ° to 158° C.

(EXAMPLE 3)

Manufacturing of 5-methoxy-3-(3-methoxy-2-methyl-4-methylsulfonyibenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione (cis and trans forms). ##STR17##

3-(3-methoxy-2-methyl-4-methylsulfonylbenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione in an amount of 6.0 g was dissolved in a mixture consisting of methanol in a volume of 20 ml and methylene chloride in a volume of 40 ml, and the solution was then added with sodium acetate in an amount of 3.38 g and subsequently with phenyltrimethyl ammonium trobromide (PTAB) in an amount of 9.31 g. The mixture was then allowed to a reaction for 3 hours under reflux. After adding sodium acetate in an amount of 1.35 g to the reacted-mixture, the mixture was further allowed to a reaction for 15 hours at an ambient temperature. The reacted-mixture was then condensed under reduced pressure, and the residue obtained was dissolved in a mixture of water and methylene chloride, then adjusted to an acidic condition with diluted hydrochloric acid for the subsequent extraction. The organic solvent layer resulted was washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation, thereby affording an oily product in an amount of 8.60 g in viscous liquid state. The crude oily product was then purified by means of column chromatography to obtain a trans-form of the objective compound in an amount of 2.35 g and the cis-form in an amount of 1.13 g. The melting points of the trans-form and the cis-form were 190°-193° C. and 169°-170° C., respectively.

(EXAMPLE 4)

Manufacturing of 5-methoxy-3-(4-methylsulfonyl-2-nitrobenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione (cis and trans forms). ##STR18##

3-(4-methylsulfonyl-2-nitrobenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione in an amount of 3.48 g (10.0 mmol) was dissolved in a mixture of acetonitrile in a volume of 10 ml and methanol in a volume of 10 ml, and the solution was then stirred for 15 hours at an ambient temperature following to an addition of both PTAB in an amount of 4.5 g (12.0 mmol) and sodium acetate in an amount of 1.7 g (20.7 mmol). After removing the solvents by distillation under reduced pressure, the solution was then added with both water and diluted hydrochloric acid to adjust it to an acidic condition and was subsequently extracted with methylene chloride. The organic solvent layer resulted was then washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation. A crude product obtained was then separated by means of thin layer chromatography using silica gel, where a mixture of chloroform and methanol at a combining ratio of 30 to 1 is used, affording a trans-form of the objective compound in an amount of 0.9 g and the cis-form in an amount of 0.45 g both in an amorphous state. The yield for the trans-form was 24% whereas that of the cis-form was 12%.

(EXAMPLE 5)

Manufacturing of 3-(3-difluoromethoxy-2-methyl-4-methylsulfonylbenzoyl)-5-methoxy-5-methylbicyclo 4,1,0!heptane-2,4-dione (cis and trans forms). ##STR19##

3-(3-difluoromethoxy-2-methyl-4-methylsulfonylbenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione in an amount of 0.70 g (1.75 mmol) was dissolved in a mixture of acetonitrile in a volume of 5 ml and methanol in a volume of 5 ml, and the solution was then stirred for 15 hours at an ambient temperature following to an addition of both PTAB in an amount of 0.8 g (2.13 mmol) and sodium acetate in an amount of 0.3 g (3.66 mmol). After removing the solvents by distillation under reduced pressure, the solution was added with both water and diluted hydrochloric acid to adjust it to an acidic condition and was subsequently extracted with methylene chloride. The organic solvent layer resulted was then washed with saturated saline solution and dried with magnesium sulfate, and the solvent remained was removed by distillation. A crude product obtained was then separated by means of thin layer chromatography using silica gel, where a mixture of chloroform and methanol at a combining ratio of 30 to 1 is used, affording a trans-form of the objective compound in an amount of 0.24 g and the cis-form in an amount of 0.20 g both in an amorphous state. The yield for the trans-form was 32% whereas that of the cis-form was 27%.

(Referential Example 2)

Manufacturing of 3-(3-difluoromethoxy-2-methyl-4-methylsultonylbenzoyl)-5-methylbicyclo 4,1,0!heptane-2,4-dione (cis-form). ##STR20##

To methylene chloride in a volume of 30 ml, were dissolved 5-ethoxycarbonyl-5-methylbicyclo 4,1,0!heptane-2,4-dione (trans-form) in an amount of 3.15 g and 3-difluoromethoxy-2-methyl-4-methylsulfonylbenzoly chloride in an amount of 4.56 g, and the solution was then fed dropwise with triethylamine in an amount of 1.67 g while stirring under cooling by using ice water. After cooling to an ambient temperature, the mixture was further stirred for 1 hour, and the reaction mixture was then washed with each of diluted hydrochloric acid, an aqueous solution of sodium hydrogencarbonate and saturated saline solution in series. Then, the organic layer was dried with magnesium sulfate, and the solvent was removed by distillation under reduced pressure, thereby affording an oily product. The product was then dissolved in acetonitrile in a volume of 30 ml and subsequently added with both triethylamine in an amount of 1.82 g and acetone cyanohydrin in an amount of 0.06 g, then the mixture was allowed to a reaction for 40 hours. After the reaction, the reaction mixture was added with diluted hydrochloric acid to extract it with methylene chloride. Then, the organic was washed with each of an aqueous solution of sodium hydrogencarbonate, water and saturated saline solution in series and dried with magnesium sulfate, and the solvent was removed by distillation under reduced pressure. The residue obtained was purified by means of silicagel column chromatography using chloroform, affording powder product in an amount of 5.03 g.

¹ H-NMR (d, CDC₃):0.73 (q, J=5, 5Hz, 1H), 1.27 (t, J=7.2 Hz, 3H), 1.46 (s, 3H), 1.66 (m, 1H), 2.28 (s, 3H), 2.3 (m, 1H), 3.23 (s, 3H), 4.18 (q, J=7.2, 2H), 6.72 (t, J=75.0, 1H), 7.11 (d, J=8.1, 1H) 7.88 (d, J=8.1, 1H), 17.42 (bs, 1H)

3-(3-difluoromethoxy-2-methyl-4-methylsulfonylberzoyl)-5-ethoxycarbonyl-5-methylbicyclo 4,1,0!heptane-2,4-dione in the trans-form in an amount of 1.84 g was dissolved in methylene chloride in a volume of 20 ml, and the solution was allowed to a reaction for 1 hour at an ambient temperature under reflux following to an addition of 1-N aqueous solution of sodium hydroxide in a volume of 11.7 ml to the solution. After proceeding hydrolysis in the above reaction, the reacted solution was then fed dropwise with both acetic acid in an amount of 0.70 g and methylene chloride in a volume of 5 ml under cooling with ice water, then neutralized and allowed to a decarboxylation reaction. After 1 hour, the organic layer resulted was separated, washed with water and subsequently with saturated saline solution and dried with magnesium sulfate. After removing the solvent, a crude crystalline product precipitated was further subjected to recrystallization procedure in methanol, thereby affording the objective compound in an amount of 0.67 g in a form of whitish crystals. The melting point of the compound was 152°-156 ° C.

¹ H-NMR (d, CDCl₃, δ ppm):0.77 (m, 1H), 1.20, 1.49 (d, J=6, 6Hz, 3H), 1.9 (m, 3H), 2.23, 2.28 (s, 3H), 2.78 (m, 1H), 3.21 (s, 3H), 6.69 (t, J=75.0, 1H), 7.05 (bd, J=8.4, 1H), 7.88 (d, J=8.4, 1H), 17.5 (bs, 1H)

(Referential Example 3) ##STR21## (1) Manufacturing of 3-difluoromethoxy-2-methyl-4-methylthiobenzoic acid

To an autoclave made of metal in a volume of 200 ml, were placed 3-hydroxy-2-methyl-4-methylthiobenzoic acid methyl ester in an amount of 22.2 g, acetonitrile in an amount of 100 ml and potassium carbonate in an amount of 13.7 g, and the mixture was allowed to a reaction for 3.5 hours at 100° C. following to a blowing of chlorodifluoro methane in an amount of 21 g into the autoclave at an ambient temperature. The reacted-solution was then poured into water and then extracted with ethyl acetate. The organic solvent layer resulted was washed with water and subsequently with saturated saline solution and then dried with magnesium sulfate, and the solvent remained was removed by distillation. The residue resulted was then purified by means of silica gel column chromatography, which uses a developer consisting of n-hexane and benzene, affording a methyl ester of the objective compound in an amount of 9.08 g. The methyl ester in an amount of 1.00 g was then dissolved in ethanol in a volume of 10 ml, and the solution was allowed to hydrolysis for 2 hours at a temperature of from 70° to 80° C. following to an addition of 1-N solution of sodium hydroxide in an amount of 7.6 ml. After removing the solvent therein by distillation, the residue was dissolved in water and then adjusted to an acidic condition with diluted hydrochloric acid for a subsequent extraction thereof with ethyl acetate. The organic solvent layer resulted was washed with saturated saline solution, then dried with magnesium sulfate, and the solvent remained was removed by distillation, thereby affording the objective compound in an amount of 0.94 g in white crystalline state. The melting point of the compound was 200°-204° C.

(2) Manufacturing of 3-difluoromethoxy-2-methyl-4-methylsulforylbenzoic acid

3-difluoromethoxy-2-methyl-4-methylthiobenzoic acid methyl ester in an amount of 4.22 g was dissolved in acetic acid in a volume of 20 ml, and the solution was then fed dropwise with 30% aqueous solution of hydrogen peroxide in an amount of 1.60 g at 60° C. After raising the temperature of the mixture to 100° C., 30% aqueous solution of hydrogen peroxide in an amount of 3.21 g was further fed dropwise to the mixture. After dropping, the mixture was allowed to a reaction for 2 hours under reflux, and the mixture was poured into water to extract it with ethyl acetate following to cooling the reacted-mixture. The organic solvent layer resulted was washed with each of hypo and saturated saline solution in series, the solvent remained was removed by distillation, thereby affording a methyl ester of the objective compound. The said methyl ester was then subjected to the same procedure as described above to obtain the objective compound in an amount of 4.28 g in whitish crystalline state. The melting point of the compound was 151°-153 ° C.

The representative examples of the compounds according to the present invention are presented in the Tables from 1 through 4 as presented below, where all compounds prepared in the examples described above are included.

                                      TABLE 1                                      __________________________________________________________________________      ##STR22##                                                                                                         Physical                                   Compound                            Constant                                   No.   R  R.sup.1                                                                               Configulation                                                                         (X)n           !mp °C.                           __________________________________________________________________________     I-1   CH.sub.3                                                                          CH.sub.3                                                                              cis    2-NO.sub.2 -4-Cl                                                                            powder                                     I-2   CH.sub.3                                                                          CH.sub.3                                                                              trans  2-NO.sub.2 -4-Cl                                                                            powder                                     I-3   CH.sub.3                                                                          CH.sub.3                                                                              cis    2-NO.sub.2 -4-CF.sub.3                                                                      powder                                     I-4   CH.sub.3                                                                          CH.sub.3                                                                              trans  2-NO.sub.2 -4-CF.sub.3                                                                      powder                                     I-5   CH.sub.3                                                                          CH.sub.3                                                                              cis    2-NO.sub.2 -4-SCH.sub.3                                                                     powder                                     I-6   CH.sub.3                                                                          CH.sub.3                                                                              trans  2-NO.sub.2 -4-SCH.sub.3                                                                     powder                                     I-7   CH.sub.3                                                                          CH.sub.3                                                                              cis    2-NO.sub.2 -4-SO.sub.2 CH.sub.3                                                             powder                                     I-8   CH.sub.3                                                                          CH.sub.3                                                                              trans  2-NO.sub.2 -4-SO.sub.2 CH.sub.3                                                             powder                                     I-9   CH.sub.3                                                                          CH.sub.3                                                                              cis    2-Cl-4-SO.sub.2 CH.sub.3                                                                    powder                                     I-10  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-Cl-4-SO.sub.2 CH.sub.3                                                                    powder                                     I-11  CH.sub.3                                                                          CH.sub.3                                                                              cis    2,3,4-Cl.sub.3                                                                              powder                                     I-12  CH.sub.3                                                                          CH.sub.3                                                                              trans  2,3,4-Cl.sub.3                                                                              125-127                                    I-13  CH.sub.3                                                                          CH.sub.3                                                                              cis    2,3-Cl.sub.2 -4-SO.sub.2 CH.sub.3                                                           powder                                     I-14  CH.sub.3                                                                          CH.sub.3                                                                              trans  2,3-Cl.sub.2 -4-SO.sub.2 CH.sub.3                                                           powder                                     I-15  CH.sub.3                                                                          CH.sub.3                                                                              cis    2,3-(CH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3                                                   powder                                     I-16  CH.sub.3                                                                          CH.sub.3                                                                              trans  2,3-(CH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3                                                   powder                                     I-17  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-18  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       168-170                                    I-19  CH.sub.3                                                                          C.sub.2 H.sub.5                                                                       cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-20  CH.sub.3                                                                          C.sub.2 H.sub.5                                                                       trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-21  CH.sub.3                                                                          CH.sub.2 CF.sub.3                                                                     cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                   I-22  CH.sub.3                                                                          CH.sub.2 CF.sub.3                                                                     trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-23  CH.sub.3                                                                          iC.sub.3 H.sub.7                                                                      cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                   I-24  CH.sub.3                                                                          iC.sub.3 H.sub.7                                                                      trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-25  CH.sub.3                                                                          H      cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                170-174                                    I-26  CH.sub.3                                                                          H      trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-27  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                169-170                                    I-28  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                190-193                                    I-29  CH.sub.3                                                                          C.sub.2 H.sub.5                                                                       cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-30  CH.sub.3                                                                          C.sub.2 H.sub.5                                                                       trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                174-176                                    I-31  CH.sub.3                                                                          nC.sub.3 H.sub.7                                                                      cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-32  CH.sub.3                                                                          nC.sub.3 H.sub.7                                                                      trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-33  CH.sub.3                                                                          iC.sub.3 H.sub.7                                                                      cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-34  CH.sub.3                                                                          iC.sub.3 H.sub.7                                                                      trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-35  CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                   cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-36  CH.sub.3                                                                          CH.sub.2 CHCH.sub.2                                                                   trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-37  CH.sub.3                                                                          CH.sub.2 C CH                                                                         cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-38  CH.sub.3                                                                          CH.sub.2 C CH                                                                         trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-39  CH.sub.3                                                                          C.sub.2 H.sub.4 OCH.sub.3                                                             cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-40  CH.sub.3                                                                          C.sub.2 H.sub.4 OCH.sub.3                                                             trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-41  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-CH.sub.3 -3-OCHF.sub.2 -4-SO.sub.2 CH.sub.3                                               powder                                     I-42  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-CH.sub.3 -3-OCHF.sub.2 -4-SO.sub.2 CH.sub.3                                               viscous                                                                        oil                                        I-43  CH.sub.3                                                                          .sup.n Bu                                                                             cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-44  CH.sub.3                                                                          .sup.n Bu                                                                             trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-45  CH.sub.3                                                                          .sup.i Bu                                                                             cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-46  CH.sub.3                                                                          .sup.i Bu                                                                             trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-47  CH.sub.3                                                                          CH.sub.2 -cPr                                                                         cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-48  CH.sub.3                                                                          CH.sub.2 -cPr                                                                         trans  2-CHa-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                      powder                                     I-49  CH.sub.3                                                                          CH.sub.2 Ph   2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-50  CH.sub.3                                                                          cC.sub.5 H.sub.9                                                                      cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-51  CH.sub.3                                                                          cC.sub.5 H.sub.9                                                                      trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-52  CH.sub.3                                                                          CH.sub.2 COCH.sub.3                                                                   cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-53  CH.sub.3                                                                          CH.sub.2 COCH.sub.3                                                                   trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-54  CH.sub.3                                                                          CH.sub.2 CH.sub.2 Cl                                                                  cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-55  CH.sub.3                                                                          CH.sub.2 CH.sub.2 Cl                                                                  trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-56  CH.sub.3                                                                          CH.sub.2 CH.sub.2 Br                                                                  cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-57  CH.sub.3                                                                          CH.sub.2 CH.sub.2 Br                                                                  trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-58  CH.sub.3                                                                          CH.sub.2 CH.sub.2 CN                                                                  cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-59  CH.sub.3                                                                          CH.sub.2 CH.sub.2 CN                                                                  trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-60  CH.sub.3                                                                          CH.sub.2 CH.sub.2 OH                                                                  cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-61  CH.sub.3                                                                          CH.sub.2 CH.sub.2 OH                                                                  trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3            I-62  CH.sub.3                                                                          C(O)H  cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-63  CH.sub.3                                                                          C(O)H  trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3            I-64  CH.sub.3                                                                          COCH.sub.3                                                                            cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-65  CH.sub.3                                                                          COCH.sub.3                                                                            trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-66  CH.sub.3                                                                          COC.sub.2 H.sub.5                                                                     cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-67  CH.sub.3                                                                          COC.sub.2 H.sub.5                                                                     trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-68  CH.sub.3                                                                          COPh   cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-69  CH.sub.3                                                                          COPh   trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                     I-70  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-CH.sub.3 -4-SO.sub.2 CH.sub.3                                                             powder                                     I-71  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-CH.sub.3 -4-SO.sub.2 CH.sub.3                                                             powder                                     I-72  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                            powder                                     I-73  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                            powder                                     I-74  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-SO.sub.2 CH.sub.3 -4-Cl                                                                   powder                                     I-75  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-SO.sub.2 CH.sub.3 -4-Cl                                                                   powder                                     I-76  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-CH.sub.3 -3-Br-4-SO.sub.2 CH.sub.3                                                        176-177                                    I-77  CH.sub.3                                                                          CH.sub.3                                                                              trans  2-CH.sub.3 -3-Br-4-SO.sub.2 CH.sub.3                                                        182 dec.                                   I-78  CH.sub.3                                                                          CH.sub.3                                                                              cis    2,3-(OCH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3                                                  183-186                                    I-79  CH.sub.3                                                                          CH.sub.3                                                                              trans  2,3-(OCH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3                                                  powder                                     I-80  CH.sub.3                                                                          H      cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-81  CH.sub.3                                                                          H      trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-82  CH.sub.3                                                                          .sup.n Pr                                                                             cis    2-Ci-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-83  CH.sub.3                                                                          .sup.n Pr                                                                             trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-84  CH.sub.3                                                                          .sup.n Oct                                                                            cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-85  CH.sub.3                                                                          .sup.n Oct                                                                            trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-86  CH.sub.3                                                                          C(O)H  cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-87  CH.sub.3                                                                          C(O)H  trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                       powder                                     I-88  CH.sub.3                                                                          COCH.sub.3                                                                            cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                   I-89  CH.sub.3                                                                          COCH.sub.3                                                                            trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                   I-90  CH.sub.3                                                                          CH.sub.3                                                                              cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                Na salt                                                                        227-233                                                                        dec.                                       __________________________________________________________________________

                                      TABLE 2                                      __________________________________________________________________________      ##STR23##                                                                     Compound                             Physical Constant                         No.   R  R.sup.1 Configulation                                                                         (X)n           !mp °C.                          __________________________________________________________________________     II-1  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-NO.sub.2 -4-Cl                                       II-2  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-NO.sub.2 -4-Cl                                       II-3  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-NO.sub.2 -4-CF.sub.3                                 II-4  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-NO.sub.2 -4-CF.sub.3                                 II-5  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-NO.sub.2 -4-SCH.sub.3                                II-6  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-NO.sub.2 -4-SCH.sub.3                                II-7  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-NO.sub.2 -4-SO.sub.2 CH.sub.3                        II-8  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-NO.sub.2 -4-SO.sub.2 CH.sub.3                        II-9  C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-Cl-4-SO.sub.2 CH.sub.3                               II-10 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-Cl-4-SO.sub.2 CH.sub.3                               II-11 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2,3,4-Cl.sub.3                                         II-12 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2,3,4-Cl.sub.3                                         II-13 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2,3-Cl.sub.2 -4-SO.sub.2 CH.sub.3                      II-14 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2,3-Cl.sub.2 -4-SO.sub.2 CH.sub.3                      II-15 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2,3-(CH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3              II-16 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2,3-(CH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3              II-17 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-18 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-19 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                        cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-20 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                        trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-21 C.sub.2 H.sub.5                                                                   CH.sub.2 CF.sub.3                                                                      cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-22 C.sub.2 H.sub.5                                                                   CH.sub.2 CF.sub.3                                                                      trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-23 C.sub.2 H.sub.5                                                                   iC.sub.3 H.sub.7                                                                       cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-24 C.sub.2 H.sub.5                                                                   iC.sub.3 H.sub.7                                                                       trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                  II-25 C.sub.2 H.sub.5                                                                   H       cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-26 C.sub.2 H.sub.5                                                                   H       trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-27 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                    II-28 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-29 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                        cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-30 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.5                                                                        trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-31 C.sub.2 H.sub.5                                                                   nC.sub.3 H.sub.7                                                                       cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                    II-32 C.sub.2 H.sub.5                                                                   nC.sub.3 H.sub.7                                                                       trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                                                powder                                    II-33 C.sub.2 H.sub.5                                                                   iC.sub.3 H.sub.7                                                                       cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-34 C.sub.2 H.sub.5                                                                   iC.sub.3 H.sub.7                                                                       trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-35 C.sub.2 H.sub.5                                                                   CH.sub.2 CHCH.sub.2                                                                    cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-36 C.sub.2 H.sub.5                                                                   CH.sub.2 CHCH.sub.2                                                                    trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-37 C.sub.2 H.sub.5                                                                   CH.sub.2CH                                                                             cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-38 C.sub.2 H.sub.5                                                                   CH.sub.2CH                                                                             trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-39 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.4 OCH.sub.3                                                              cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-40 C.sub.2 H.sub.5                                                                   C.sub.2 H.sub.4 OCH.sub.3                                                              trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3           II-41 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               cis    2-CH.sub.3 -3-OCHF.sub.2 -4-SO.sub.2 CH.sub.3          II-42 C.sub.2 H.sub.5                                                                   CH.sub.3                                                                               trans  2-CH.sub.3 -3-OCHF.sub.2 -4-SO.sub.2 CH.sub.3          __________________________________________________________________________

                                      TABLE 3                                      __________________________________________________________________________      ##STR24##                                                                     Compound                               Physical Constant                       No.   R   R.sup.1  Configulation                                                                         (X)n           !mp °C.                        __________________________________________________________________________     III-1 iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-NO.sub.2 -4-Cl                                     III-2 iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-NO.sub.2 -4-Cl                                     III-3 iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-NO.sub.2 -4-CF.sub.3                               III-4 iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-NO.sub.2 -4-CF.sub.3                               III-5 iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-NO.sub.2 -4-SCH.sub.3                              III-6 iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-NO.sub.2 -4-SCH.sub.3                              III-7 iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-NO.sub.2 -4-SO.sub.2 CH.sub.3                      III-8 iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-NO.sub.2 -4-SO.sub.2 CH.sub.3                      III-9 iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-Cl-4-SO.sub.2 CH.sub.3                             III-10                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-Cl-4-SO.sub.2 CH.sub.3                             III-11                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2,3,4-Cl.sub.3                                       III-12                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2,3,4-Cl.sub.3                                       III-13                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2,3-Cl.sub.2 -4-SO.sub.2 CH.sub.3                    III-14                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2,3-Cl.sub.2 -4-SO.sub.2 CH.sub.3                    III-15                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2,3-(CH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3            III-16                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2,3-(CH.sub.3).sub.2 -4-SO.sub.2 CH.sub.3            III-17                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-18                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-19                                                                               iC.sub.3 H.sub.7                                                                   C.sub.2 H.sub.5                                                                         cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-20                                                                               iC.sub.3 H.sub.7                                                                   C.sub.2 H.sub.5                                                                         trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-21                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.2 CF.sub.3                                                                       cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-22                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.2 CF.sub.3                                                                       trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-23                                                                               iC.sub.3 H.sub.7                                                                   iC.sub.3 H.sub.7                                                                        cis    2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-24                                                                               iC.sub.3 H.sub.7                                                                   iC.sub.3 H.sub.7                                                                        trans  2-Cl-3-OCH.sub.3 -4-SO.sub.2 CH.sub.3                III-25                                                                               iC.sub.3 H.sub.7                                                                   H        cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-26                                                                               iC.sub.3 H.sub.7                                                                   H        trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-27                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-28                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-29                                                                               iC.sub.3 H.sub.7                                                                   C.sub.2 H.sub.5                                                                         cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-30                                                                               iC.sub.3 H.sub.7                                                                   C.sub.2 H.sub.5                                                                         trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-31                                                                               iC.sub.3 H.sub.7                                                                   nC.sub.3 H.sub.7                                                                        cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-32                                                                               iC.sub.3 H.sub.7                                                                   nC.sub.3 H.sub.7                                                                        trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-33                                                                               iC.sub.3 H.sub.7                                                                   iC.sub.3 H.sub.7                                                                        cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-34                                                                               iC.sub.3 H.sub.7                                                                   iC.sub.3 H.sub.7                                                                        trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-35                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.2 CHCH.sub.2                                                                     cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-36                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.2 CHCH.sub.2                                                                     trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-37                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.2 CCH                                                                            cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-38                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.2 CCH                                                                            trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-39                                                                               iC.sub.3 H.sub.7                                                                   C.sub.2 H.sub.4 OCH.sub.3                                                               cis    2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-40                                                                               iC.sub.3 H.sub.7                                                                   C.sub.2 H.sub.4 OCH.sub.3                                                               trans  2-CH.sub.3 -3-OCH.sub.3 -4-SO.sub.2 CH.sub.3         III-41                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 cis    2-CH.sub.3 -3-OCHF.sub.2 -4-SO.sub.2 CH.sub.3        III-42                                                                               iC.sub.3 H.sub.7                                                                   CH.sub.3 trans  2-CH.sub.3 -3-OCHF.sub.2 -4-SO.sub.2 CH.sub.3        __________________________________________________________________________

                  TABLE 4                                                          ______________________________________                                          ##STR25##                                                                                             Confi-          Physical                               Compound                gula-           Constant                               No.     R       R.sup.1 tion  (X)n        !mp °C.                       ______________________________________                                         IV-1    CH.sub.3                                                                               CH.sub.3                                                                               cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                                                          powder                                 IV-2    CH.sub.3                                                                               CH.sub.3                                                                               trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                                                          powder                                 IV-3    CH.sub.3                                                                               C.sub.2 H.sub.5                                                                        cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-4    CH.sub.3                                                                               C.sub.2 H.sub.5                                                                        trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-5    CH.sub.3                                                                               nC.sub.3 H.sub.7                                                                       cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-6    CH.sub.3                                                                               nC.sub.3 H.sub.7                                                                       trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-7    C.sub.2 H.sub.5                                                                        CH.sub.3                                                                               cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-8    C.sub.2 H.sub.5                                                                        CH.sub.3                                                                               trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-9    C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                        cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-10   C.sub.2 H.sub.5                                                                        C.sub.2 H.sub.5                                                                        trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-11   C.sub.2 H.sub.5                                                                        iC.sub.3 H.sub.7                                                                       cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-12   C.sub.2 H.sub.5                                                                        iC.sub.3 H.sub.7                                                                       trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-13   iC.sub.3 H.sub.7                                                                       CH.sub.3                                                                               cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-14   iC.sub.3 H.sub.7                                                                       CH.sub.3                                                                               trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-15   iC.sub.3 H.sub.7                                                                       C.sub.2 H.sub.5                                                                        cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-16   iC.sub.3 H.sub.7                                                                       C.sub.2 H.sub.5                                                                        trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-17   iC.sub.3 H.sub.7                                                                       nC.sub.3 H.sub.7                                                                       cis   2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  IV-18   iC.sub.3 H.sub.7                                                                       nC.sub.3 H.sub.7                                                                       trans 2-CH.sub.3 -6-SO.sub.2 CH.sub.3                  ______________________________________                                    

¹ H-NMR Data (CDCl₃, δ ppm)

(I-1) 16. 80(bs, 1H, OH)8.17(m, 1H, ArH)7.65(m, 1H, ArH)7.24(m, 1H, ArH) 3.53, 3.30(3H, OCH₃)2.17(m, 1H)1.86(m, 2H)1.65, 1.42(3H, CH₃)1.10(m, 1H)

(I-2) 16.94, 16.44(1H, OH)8.20(m, 1H, ArH)7.65(m, J=8.1Hz, 1H, ArH) 7.18(d, J=8.1Hz, 1H, ArH)3.32, 3.00(3H, OCH₃)2.17(m, 2H)1.66(m, 1H) 1.63, 1.32(3H, CH₃)0.76(m, 1H)

(I-3) 16.60(bs, 1H, OH)8.45(s, 1H, ArH)7.96(d, J=6.9Hz, 1H, ArH) 7.39(d, J=6.9Hz, 1H, ArH)3.54, 3.30(3H, OCH₃ )2.19(m, 1H)1.88(m, 2H) 1.67, 1.43(3H, CH₃)1.20(m, 1H)

(I-4) 16.73, 16.23(1H, OH)8.50(s, 1H, ArH)7.95(d, J=7.6Hz, 1H, ArH) 7.38(d, J=7.6Hz, 1H, ArH)3.34, 3.02(3H, OCH₃)2.16(m, 2H)1.67(m, 1H) 1.69, 1.33(3H, CH₃)0.78(m,1H)

(I-6) 17.20, 16.62(1H, OH)8.00(m, 1H, ArH)7.46(m, 1H, ArH)7.14(m, 1H, ArH) 3.30, 3.00(3H, OCH₃)2.58(s, 3H, SCH₃)2.24-2.05(m, 2H) 1.70-1.53(m, 4H) 1.30(s, 3H, CH₃)0.77(m, 1H)

(I-7) 16.45(bs, 1H, OH)8.74(m, 1H, ArH)8.26(m, 1H, ArH)7.46(m, 1H, ArH) 3.53, 3.30(3H, OCH₃)3.46, 3.16(3H, SO₂ CH₃)2.21(m, 1H)1.92(m, 2H) 1.68, 1.43(3H, CH₃)1.13(m, 1H)

(I-8) 16.58, 16.17(1H, OH)8.76(m, 1H, ArH)8.25(d, J=7.7Hz, 1H, ArH) 7.45(d, J=7.7Hz, 1H, ArH)3.34, 3.16(3H, OCH₃)3.24, 3.02(3H, SO₂ CH₃) 2.20(m, 1H)1.71(m, 2H)1.64, 1.32(3H, CH₃)0.78(m, 1H)

(I-9) 17.18, 16.90(1H, OH)7.91(m, 2H, ArH)7.37(m, 1H, ArH)3.53, 3.35(3H, OCH₃) 3.14, 3.11 (3H, SO₂ CH₃)2.25(m, 1H) 1.88(m, 2H) 1.63, 1.54(3H, CH₃) 1.15(m, 1H)

(I-10) 17.28, 16.55(1H, OH)7.98(d, J=7.4Hz, 1H, ArH)7.88(d, J=7.4Hz, 1H, ArH) 7.30(d, J=8.5Hz, 1H, ArH)3.31, 3.13(3H, OCH₃)3.10(s, 3H, SO₂ CH₃)2.21(m, 2H) 1.67(m, 1H)1.66, 1.38(3H, CH₃)0.82(m, 1H)

(I-11) 17.22, 16.94(1H, OH)7.45(m, 1H, ArH)7.18-6.95(m, 1H, ArH) 3.52, 3.35(3H, OCH₃)2.28-1.70(m, 3H)1.64-1.52(3H, CH₃)1.40-1.05(m, 1H)

(I-12) 17.35, 16.55(1H, OH)7.45(m, 1H, ArH)7.20-6.92(m, 1H, ArH) 3.30, 3.12(3H, OCH₃)2.30, 2.00(m, 2H)1.72-1.36(m, 4H)0.95-0.72(m, 1H)

(I-13) 17.10, 16.78(1H, OH)8.15(m, 1H, ArH)7.30(m, 1H, ArH)3.50, 3.35(3H, OCH₃) 3.28(s, 3H, SO₂ CH₃)2.25(m, 1H)1.90(m, 2H)1.60, 1.50(3H, CH₃)1.15(m, 1H)

(I-14) 8.15 (m, 1H, ArH)7.36(m, 1H, ArH)3.32(s, 3H, SO₂ CH₃) 3.32, 3.13(3H, OCH₃) 2.21(m, 2H)1.68(m, 1H)1.58, 1.38(3H, CH₃)0.82(m, 1H)

(I-15) 17.65, 17.41(1H, OH)7.98(m, 1H, ArH)7.10(m, 1H, ArH)3.55, 3.35(3H, OCH₃) 3.10(3H, SO₂ CH₃)2.65(m, 3H, ArCH₃)2.22(m, 3H, ArCH₃)2.00(m, 1H) 1.85(m, 2H) 1.65, 1.52(3H, CH₃)1.30, 1.10(m, 1H)

(I-16)17.10(1H, OH)7.95(m, 1H, ArH)7.05(m, 1H, ArH)3.35, 3.12(3H, OCH₃) 3.10(3H, SO₂ CH₃)2.65(m, 3H, ArCH₃)2.20(s, 3H, ArCH₃)2.15(m, 2H) 1.62, 1.35(3H, CH₃)0.80(m, 1H)

(I-17) 7.95(m, 1H, ArH)7.12(m, 1H, ArH)4.07(m, 1H, ArOCH₃)3.53, 3.37(3H, OCH₃)3.26 (m, 3H, SO₂ CH₃)2.24 (m, 1H)1.90(m, 2H) 1.64, 1.52(3H, CH₃)1.13(m, 1H)

(I-18) 7.92(m, 1H, ArH)7.06(m, 1H, ArH)4.08(s, 3H, ArOCH₃) 3.32, 3.13(3H, OCH₃)3.27(s, 3H, SO₂ CH₃)2.20(m, 2H)1.68(m, 1H) 1.70, 1.37(3H, CH₃)0.82(m, 1H)

(I-19) 7.94(m, 1H, ArH)7.27(m, 1H, ArH)4.06(m, 3H, ArOCH₃) 3.69-3.40(m, 2H, OCH₂ CH₃)3.26(s, 3H, SO₂ CH₃)2.23(m, 6H)2.00-1.80(m, 2H)1.64, 1.52(3H, CH₃)1.20, 1.17(m, 4H)

(I-20) 7.93(m, 1H, ArH)7.10(m, 1H, ArH)4.07(s, 3H, ArOCH₃)3.42, 3.10(2H, OCH₂ CH₃)3.28(s, 3H, SO₂ CH₃)2.20(m, 2H)1.67(m, 1H)1.68, 1.37(3H, CH₃) 1.15(m, 3H, OCH₂ CH₃)

(I-22) 7.90(m, 1H, ArH)7.10(m, 1H, ArH)4.10(m, 5H)3.28(m, 3H, SO₂ CH₃) 2.20(m, 2H)1.70 (m, 1H)1.45, 1.25(3H, CH₃)0.85(m, 1H)

(I-24) 7.93(m, 1H, ArH)7.14(m, 1H, ArH)4.07(m, 3H, OCH₃)3.98, 3.84(1H, CH)3.44, 3.38(3H, SO₂ CH₃)2.28(m, 1H)2.03(m, 1H)1.83(m, 1H)1.63, 1.50(3H, CH₃) 1.34, 1.20(m, 6H, CH(CH₃)₂)

(I-25) 17.60(s, 1H, OH)7.85(d, 1H, ArH)6.95(d, 1H, ArH)3.98(s, 3H, ArOCH₃)3.80(bs, 1H, OH)3.25(s, 3H, SO₂ CH₃)2.25(m, 2H)2.24(s, 3H, ArCH₃)1.70(m, 1H)1.48(s, 3H, CH₃)0.92(m, 1H)

(I-26)17.57(s, 1H, OH)7.81(d, 1HArH)6.99(d, 1H, ArH)3.96(s, 3H, ArOCH₃) 3.24(s, 1H, SO₂ CH₃)2.35(bs, 1H, OH)2.24(s, 3H, ArCH₃)2.17(m, 2H) 1.66(m, 1H)1.46(s, 3H, CH₃)0.80(m, 1H)

(I-27) 17.48(bs, 1H, OH)7.82(m, 1H, ArH)6.95(m, 1H, ArH)3.95(s, 3H, ArOCH₃)3.53, 3.38(3H, OCH₃)3.25(s, 3H, SO₂ CH₃)2.22(m, 4H)1.85(m, 2H) 1.63, 1.51(3H, CH₃)1.20(m, 1H)

(I-28) 7.80(m, 1H, ArH)7.12(m, 1H, ArH)3.96(s, 3H, ArOCH₃) 3.48, 3.31, 3.11(3H, OCH₃)3.25(m, 3H, SO2CH₃)2.24-2.01(m, 4H)1.60(m, 2H) 1.66, 1.37(3H, CH₃)0.96-0.77(m, 1H)

(I-29) 17.58, 17.30(1H, OH)7.80(m, 1H, ArH)6.86(m, 1H, ArH)3.95(s, 3H, ArOCH₃) 3.57(m, 2H, OCH₂ CH₃)3.22(s, 3H, SO₂ CH₃)2.23(m, 4H)1.90(m, 2H) 1.62, 1.51(3H, CH₃)1.25(m, 3H, OCH₂ CH₃)1.12(m, 1H)

(I-30) 7.81(m, 1H, ArH)6.93(m, 1H, ArH)3.97(s, 3H, ArOCH₃)3.45, 3.04(2H, OCH₂ CH₃)3.25(s, 3H, SO₂ CH₃)2.20(m, 4H)1.62(m, 1H)1.38, 1.25(3H, CH₃) 1.15(m, 3H, OCH₂ CH₃)0.80(m, 2H)

(I-31) 17.60, 17.30(1H, OH)7.80(m, 1H, ArH)6.95(m, 1H, ArH)3.95(m, 1H, ArOCH₃) 3.90-3.26(m, 2H, CH₂ CH₂ CH₃)3.22(m, 3H, SO₂ CH₃)2.22(m, 3H, ArCH₃) 2.10-1.50(m, 8H)1.38-1.04(m, 1H)1.02-0.83(m, 3H, CH₂ CH₃)

(I-32) 17.60, 16.84(1H, OH)7.80(m, 1H, ArH)6.95(m, 1H, ArH)3.98(s, 3H, ArOCH₃)3.40-2.85(m, 2H, CH₂ CH₂ CH₃)3.25(s, 3H, SO₂ CH₃)2.30-2.12(m, 1H) 2.22(s, 3H, ArCH₃)1.70-1.38(m, 7H)0.93-0.72(m, 4H)

(I-33) 7.81(m, 1H, ArH)6.95(m, 1H, ArH) 3.95(m, 3H, ArOCH₃)3.82(m, 1H, CH) 3.24(s, 3H, SO₂ CH₃)2.22(m, 3H, ArCH₃)2.10-1.92(m, 1H)1.90-1.65(m, 2H) 1.61, 1.50(3H, CH₃)1.40-1.10(m, 7H)

(I-34) 7.82(m, 1H, ArH)6.95(m, 1H, ArH)3.96(s, 3H, ArOCH₃)3.65(m, 1H, CH) 3.25(s, 3H, SO₂ CH₃)2.23(m, 3H, ArCH₃ )2.20-1.85(m, 2H)1.78-1.48(m, 1H)1.65-1.40(3H, CH₃)1.17-0.95(m, 6H, CH(CH₃)₂)0.92-0.70(m, 1H)

(I -35) 17.60, 17.26(bs, 1H, OH)7.81(m, 1H, ArH)6.95(m, 1H, ArH)6.10-5.86(m, 1H)5.43-5.11(m, 2H)4.40-3.92 (m, 2H, OCH₂)3.95(s, 3H, ArOCH₃) 3.24(s, 3H, SO₂ CH₃)2.27, 2.22(s, 3H, ArCH₃)2.07-1.75 (m, 2H)1.69, 1.55(s, 3H, CH₃)1.43-1.13(m, 2H)

(I-36) 17.55, 16.88(bs, 1H, OH)7.77(m, 1H, ArH)6.92(m, 1H, Ar )5.90-5.70(m, 1H)5.30-5.10(m, 2H)3.96-3.52(m, 2H, OCH₂)3.95(s, 3H, ArOCH₃) 3.23(s, 3H, SO₂ CH₃)2.24, 2.21(s, 3H, ArCH₃)2.28-1.91(m, 1H)1.68, 1.39(s, 3H, CH₃)1.66-1.57 (m, 1H)0.90-0.72(m, 2H)

(I-37) 17.55(bs, 1H, OH)7.90(m, 1H, ArH)6.96(m, 1H, ArH)4.33(m, 2H, OCH₂) 3.96(s, 3H, ArOCH₃)3.25(s, 3H, SO₂ CH₃)2.30(m, 5H)1.90(m, 2H) 1.68, 1.58(3H, CH₃)1.12(m, 1H)

(I-38) 7.83(m, 1H, ArH)7.00(m, 1H, ArH)3.97(s, 3H, ArOCH₃)3.90(m, 2H, OCH₂) 3.26(s, 3H, SO₂ CH₃)2.47(s, 1H, CH)2.22(m, 4H)1.66(m, 2H)1.43(s, 3H, CH₃)0.77(m, 1H)

(I-41) 17.42(bs, 1H, OH)7.92(m, 1H, ArH)7.13(m, 1H, ArH)6.54(d, J _(HF) =74Hz, 1H, CF₂ H)3.53, 3.36(3H, OCH₃)3.22(s, 3H, SO₂ CH₃)2.23(m, 4H)1.92(m, 2H) 1.64, 1.51(3H, CH₃)1.13(m, 1H)

(I-42) 17.49, 16.84(1H, OH)7.91(m, 1H, ArH)7.13(m, 1H, ArH)6.56(d, J_(HF) =75Hz, 1H, CF₂ H)3.31, 3.11(3H, OCH₃)3.24(s, 3H, SO₂ CH₃)2.29(s, 3H, ArCH₃) 2.17(m, 1H)1.67(m, 1H)1.66, 1.37(3H, CH₃)0.79(m, 1H)

(I-43) 17.58, 17.28(bs, 1H, OH)7.84, 7.81(d, 1H, ArH)6.98, 6.93(d, 1H, ArH) 3.97, 3.95(s, 3H, ArOCH₃)3.90-3.35(m, 2H)3.24(s, 3H, SO₂ CH₃) 2.26, 2.21(s, 3H, ArCH₃)2.30-1.25(m, 7H) 1.62, 1.50(s, CH₃)1.12, 0.95(m, 1H) 0.98, 0.88(t, 3H)

(I-44) 17.60, 16.93(bs, 1H, OH)7.83, 7.80(d, 1H, ArH)6.96, 6.92(d, 1H, ArH) 3.97(s, 3H, ArOCH₃)3.38, 2.97(m, 2H)3.25(s, 3H, SO₂ CH₃)2.26, 2.22(s, 3H, ArCH₃) 2.28-1.90 (m, 2H)1.65, 1.36(s, 3H, CH₃) 1.65-1.23 (m, 4H)0.91(t, 3H) 1.86, 0.77(m, 1H)

(I-45) 17.60, 17.27(bs, 1H, OH)7.80(m, 1H, ArH)6.95(m, 1H, ArH) 3.95(s, 3H, ArOCH₃)3.61-3.26(m, 2H, OCH₂)3.23(s, 3H, SO₂ CH₃)2.27, 2.22(s, 3H, ArCH₃)2.03-1.74(m, 3H)1.62, 1.51(s, 3H, CH₃)1.54(m, 1H)1.31-1.07(m, 1H) 1.02-0.83(m, 6H, CH₃)0.53(m, 2H)0.13(m, 1H)

(I-46) 17.62, 16.94 (bs, 1H, OH)7.80(m, 1H, ArH)6.94(m, 1H, ArH) 3.96(s, 3H, ArOCH₃)3.25(s, 3H, SO₂ CH₃)3.18-2.82(m, 2H, OCH₂)2.24, 2.22(s, 3H, ArCH₃)2.17(m, 1H)1.75(m, 1H)1.65, 1.37(s, 3H, CH₃)1.62(m, 1H)0.92-0.76(m, 8H)

(I-48) 17.60, 16.89(bs, 1H, OH)7.80(d, 1H, ArH)6.93(d, 1H, ArH) 3.96(s, 3H, ArOCH₃)3.25(s, 3H, SO₂ CH₃)3.16-2.87(m, 2H, OCH₂)2.25, 2.22(s, 3H, ArCH₃)2.20-1.89(m, 1H)1.66, 1.35(s, 3H, CH₃)1.62(m, 1H)1.01-0.83(m, 1H) 0.77(m, 1H)0.53(m, 2H)0.13(m, 1H)

(I-49) 17.62, 17.35(bs, 1H, OH)7.85(m, 1H, ArH)7.52-7.20(m, 5H, PhH) 6.96(m, 1H, ArH)4.90-4.52(m, 2H, CH₂ Ph)3.98(s, 3H, ArOCH₃)3.25(s, 3H, SO₂ CH₃) 2.27, 2.24(s, 3H, ArCH₃)2.11-1.72(m, 2H)1.71, 1.60(s, 3H, CH₃ )1.44-1.17(m, 2H)

(I-50) 7.80(m, 1H, ArH)6.95(m, 1H, ArH)4.20-3.95(m, 1H, OCH)3.97(s, 3H, ArOCH₃) 3.25(s, 3H, SO₂ CH₃)2.27, 2.22(s, 3H, ArCH₃)2.08-1.35(m, 11H)1.63, 1.51(s, 3H, CH₃)1.16(m, 1H)

(I-51) 7.81(m, 1H, ArH)6.97(m, 1H, ArH)4.32-3.80(m, 1H, OCH)3.99(s, 3H, ArOCH₃) 3.26(s, 3H, SO₂ CH₃)2.26(s, 3H, ArCH₃)2.27-1.88(m, 1H )1.82-1.25(m, 10H) 1.64, 1.37(s, 3H, CH₃)0.90-0.72(m, 1H)

(I-53) 17.68, 16.91(bs, 1H, OH)7.80(m, 1H, Arh)6.94(m, 1H, ArH)4.10-3.68(m, 2H, CH₂ Ac)3.97(s, 3H ,ArOCH₃)3.26(s, 3H, SO₂ CH₃)2.31-2.09(m, 8H) 1.70, 1.38(s, 3H, CH₃)1.71-1.25(m, 1H)0.95-0.76(m, 1H)

(I-54) 17.58, 17.23(bs, 1H, OH)7.81(m, 1H, ArH)6.95(m, 1H, ArH)4.10-3.58(m, 4H)3.95(s, 3H, ArOCH₃)3.23 (s, 3H, SO₂ CH₃)2.25(m, 1H) 2.25, 2.22(s, 3H, ArH)2.07-1.78(m, 1H)1.65, 1.55(s, 3H, CH₃)1.33-1.06(m, 1H)

(I-55) 17.67, 16.95(bs, 1H, OH)7.81(m, 1H, ArH)6.98(m, 1H, ArH) 3.97(s, 3H, ArOCH₃)3.80-3.52 (m, 4H)3.22(s, 3H, SO₂ CH₃)2.30-1.85(m, 2H) 2.23(s, 3H, ArH)1.70, 1.40(s, 3H, CH₃)1.68-1.54(m, 1H)0.90-0.76(m, 1H)

(I-56) 17.55, 17.23(bs, 1H, OH)7.80(m, 1H, ArH)6.95(m, 1H, ArH)4.30-4.06(m, 1H)3.95(s, 3H, ArOCH₃)3.90-3.45 (m, 3H)3.24(s, 3H, S₂ CH₃) 2.45, 2.22(s, 3H, ArH)2.30-2.10(m, 1H)2.05-1.76(m, 2H)1.64, 1.53(s, 3H, CH₃)1.34-1.25(m, 1H)

(I-57) 17.65, 16.96(bs, 1H, OH)7.82(d, J=8.1Hz, 1H, ArH)7.02(d, J=8.1Hz, 1H, Arh) 3.97(s, 3H, ArOCH₃)3.81-3.69(m, 2H)3.42-3.21(m, 2H)3.26(s, 3H, SO₂ CH₃)2.27-1.92(m, 2H)2.26, 2.23(s, 3H, ArH)1.69, 1.40(s, 3H, CH₃)1.67-1.60(m, 1H) 0.92-0.76(m, 1H)

(I-58) 17.58, 17.20(bs, 1H, OH)7.82(m, 1H, ArH)6.95(m, 1H, ArH)4.13-3.62(m, 2H)3.96(s, 3H, ArOCH₃)3.24(s, 3H, SO₂ CH₃)2.77-2.56(m, 2H)2.30-2.16(m, 1H)2.26, 2.21(s, 3H, ArH)2.08-1.79(m, 2H)1.66, 1.55(s, 3H, CH₃)1.32-1.07(m, 1H)

(I-59) 17.67, 16.93(bs, 1H, OH)7.80(d, J=7.5Hz, 1H, ArH)7.02(d, J=7.5Hz, 1H, ArH)3.97(s, 3H, ArOCH₃)3.62-3.20(m, 2H)3.23(s, 3H, SO₂ CH₃)2.55(m, 2H)2.30-1.95(m, 2H)2.25, 2.21(s, 3H, ArH)1.70, 1.40(s, 3H, CH₃)1.65(m, 1H)0.93-0.77(m, 1H)

(I-60) 17.62, 16.87(bs, 1H, OH)7.80(m, 1H, ArH)7.00(m, 1H, ArH) 3.95(s, 3H, ArOCH₃)3.68(m, 2H, CH₂ OH)3.52-3.05(m, 2H, OCH₂)3.25(s, 3H, SO₂ CH₃)2.26, 2.24(s, 3H, ArCH₃)2.16(m, 2H)2.10-1.75(m, 2H)1.68, 1.40(s, 3H, CH₃) 1.66(m, 1H)0.96-0.77(m, 1H)

(I-62)17.76, 17.23(bs, 1H, OH)8.10, 8.00(s, 1H, CHO)7.85, 7.82(d, 1H, ArH) 7.05, 6.96(d, 1H, ArH)3.97, 3.96(s, 3H, ArOCH₃)2.40-1.70(m, 3H)3.24(s, 3H, SO₂ CH₃)2.26, 2.23(s, 3H, ArCH₃)1.80, 1.71(s, CH₃)1.61, 1.52(m, 1H)

(I-64) 17.78, 17.29(bs, 1H, OH)7.83, 7.80(d, 1H, ArH)7.05, 6.96(d, 1H, ArH) 3.95, 3.93(s, 3H, ArOCH₃)3.24(s, 3H, SO₂ CH₃)2.36, 2.21(s, 3H, ArCH₃)2.30-1.40 (m, 4H)2.18, 2.15(s, 3H, COCH₃)1.75, 1.64(s, CH₃)

(I-65) 17.42(s, 1H, OH)7.80(d, 1H, ArH)6.98(d, 1H, ArH)3.93(s, 3H, ArOCH₃)3.24(s, 3H, SO₂ CH₃)2.43(m, 1H)2.20(m, 1H)2.21(s, 3H, ArCH₃)2.03(s, 3H, COCH₃) 1.62(m, 1H)1.60(s, 3H, CH₃)0.87(m, 1H)

(I-66) 7.83, 7.78(d, 1H, ArH)7.03, 6.96(d, 1H, ArH)3.95, 3.93(s, 3H, ArOCH₃)3.24(s, 3H, SO₂ CH₃)2.26, 2.21(s, 3H, ArCH₃)2.60-1.40(m, 6H)1.74, 1.63(s, CH₃) 1.18, 1.08(t, 3H)

(I-67) 7.83(d, 1H, ArH)6.98(d, 1H, ArH)3.95(s, 3H, ArOCH₃)3.25(s, 3H, SO₂ CH₃)2.46(m, 1H)2.32(q, 2H)2.30(m, 1H)2.24(s, 3H, ArCH₃)1.62(s, 3H, CH₃) 1.16(m, 1H)1.12(t, 3H)0.91(m, 1H)

(I-68) 17.81, 17.30(bs, 1H, OH)8.15-7.35(m, 6H, ArH)7.08, 7.00(d, 1H, ArH) 3.97, 3.93(s, 3H, ArOCH₃)3.26, 3.22(s, 3H, SO₂ CH₃)2.40-1.50(m,4H) 2.30, 2.25(s, 3H, ArCH₃)1.92, 1.18(s, CH₃)

(I-69) 17.43(s, 1H, OH)7.97(d, 2H, ArH)7.85(d, 1H, Ar)7.61(m, 1H, Ar) 7.47(m, 2H, Ar)7.02(d, 1H, ArH)3.96(s,3H, ArOCH₃)3.25(s, 3H, SO₂ CH₃) 2.57(m, 1H)2.32(m, 1H)2.23(s, 3H, ArCH₃)1.76(s, 3H, CH₃)1.70(m, 1H) 1.00(m, 1H)

(I-70) 17.60, 17.35(bs, 1H, OH)7.76(m, 2H, ArH)7.27, 7.16(m, 1H, ArH) 3.53, 3.34(s, 3H, OCH₃)3.07, 3.04(s, 3H, SO₂ CH₃)2.35, 2.32(s, 3H, ArCH₃) 2.28, 1.96(m , 1H)1.95, 1.53(m, 1H)1.81(m, 1H)1.60, 1.50(s, 3H, CH₃) 1.35, 1.05(m, 1H)

(I-71) 17.65, 17.00(bs, 1H, OH)7.76(m, 2H, ArH)7.24(m, 1H, ArH) 3.30, 3.10(s, 3H, OCH₃)3.05(s, 3H, SO₂ CH₃)2.36, 2.33(s, 3H, ArCH₃) 1.65, 1.36(s, 3H, CH₃)0.93, 0.74(m, 1H)

(I-74) 17.00, 16.91(bs, 1H, OH)7.96(m, 1H, ArH)7.61(m, 1H, ArH) 7.37, 7.11(m, 1H, ArH)3.51, 3.34(s, 3H, OCH₃)3.14(s, 3H, SO₂ CH₃)2.20(m, 1H) 1.86(m, 2H)1.65, 1.48(s, 3H, CH₃)1.43, 1.10(m, 1H)

(I-75) 17.08, 16.60(bs, 1H, OH)8.00(m, 1H, ArH)7.60 (m, 1H, ArH) 7.27, 7.08 (m, 1H)3.62, 3.31(s, 3H, OCH₃)3.15, 3.14(s, 3H, SO₂ CH₃)2.16(m, 1H)1.64 (m, 2H)1.79, 1.35(s, 3H, CH₃)0.95, 0.77(m, 1H)

(I-76) 7.92(m, 1H, ArH)7.00(m, 1H, ArH)3.25(m, 6H)2.25(bs, 3H, ArCH₃) 1.91(1H )1.79(m, 1H)1.58(m, 1H)1.37(s, 3H, CH₃)1.12, 0.76(m, 1H)

(I-77) 17.50(bs, 1H, OH)8.07(m, 1H, ArH)7.16(m, 1H, ArH)3.33(s, 3H, SO₂ CH₃. 10(s, 3H, OCH₃)2.39(bs, 3H, ArCH₃)2.23(m, 1H)2.15(m, 1H)1.66(m, 1H) 1.36(s, 3HH₃)0.74, 1.60(m, 1H)

(I-78) 17.32, 17.03(bs, 1H, OH)7.72, 7.69(d, 1H, ArH)7.11, 6.98(d, 1H, ArH) 4.01(s, 3H, ArOCH₃)4.01(s, 3H, ArOCH₃)3.93, 3.90(s, 3H, ArOCH₃)3.52, 3.35(s, 3H, OCH₃)3.24, 3.23(s, 3H, SO₂ CH₃)2.30-1.70(m, 3H)1.61, 1.53(s, SH, CH₃)1.35, 1.08(m, 1H)

(I-79) 17.47, 16.63(bs, 1H, OH)7.72, 7.69(d, 1H, ArH)7.12, 6.93(d, 1H, ArH) 4.04, 4.00(s, 3H, ArOCH₃)3.99, 3.97(s, 3H, ArOCH₃)3.30, 3.17(s, 3H, OCH₃)3.27(s, 3H, SO₂ CH₃)2.30-1.35(m, 3H)1.66, 1.39(s, 3H, CH₃)0.93, 0.77(m, 1H)

(I-80) 17.20(bs, 1H, OH)7.93(m, 1H, ArH)7.09(m, 1H, ArH)4.08(s, 3H, OCH₃) 3.26(s, 3H, SO₂ CH₃)2.35-2.10(m, 2H)1.72(m, 1H)1.71, 1.50(s, 3H, CH₃)0.93(m, 1H)

(I-81) 7.90 (m, 1H, ArH)7.10(m, 1H, ArH)4.07(s, 3H, OCH₃)3.26(s, 3H, SO₂ CH₃) 2.35-1.40 (m, 3H)1.69, 1.44(s, 3H, CH₃)0.94, 0.82 (m, 1H)

(I-82) 7.93(m, 1H, ArH)7.12(m, 1H, ArH)4.05(bs, 3H, OCH₃)3.87-3.25(m, 2H) 3.25(s, 3H, SO₂ CH₃)2.35-1.20(m, 5H)1.64, 1.52(s, 3H, CH₃)1.15-0.80(m, 1H) 1.01, 0.89(t, 3H, CH₃)

(I-83) 7.92 (m, 1H, ArH)7.18, 7.02 (m, 1H, ArH)4.09, 4.07(s, 3H, OCH₃)3.28(s, 3H, SO₂ CH₃)3.45-2.90(m, 2H)2.30-2.00(m, 2H)1.75-1.20(m, 3H)1.67, 1.38(s, 3H, CH₃) 1.00-0.75(m, 4H)

(I-84) 7.93(m, 1H, ArH)7.12(m, 1H, ArH)4.08, 4.04(br, 3H, OCH₃)3.90-3.25(m, 2H)3.27(s, 3H, SO₂ CH₃)2.30-1.20(m, 15H)1.63, 1.53(s, 3H, CH₃)1.20-0.80(m, 4H)

(I-85) 7.93(m, 1H, ArH)7.24-6.94(m, 1H, ArH)4.08(s, 3H, OCH₃) 3.27(s, 3H, SO₂ CH₃)3.50-2.90(m, 2H)2.30-1.10(m, 15H)1.67, 1.37(s, 3H, CH₃)0.97-0.74(m, 4H)

(I-86) 17.3, 16.0(bs, 1H, OH)8.11, 8.00(s, 1H, COH)7.94(m, 1H, ArH)7.22-7.05(m, 1H, ArH)4.06(s, 3H, OCH₃)3.25(s, 3H, SO₂ CH₃)2.4-1.6(m, 3H) 1.82, 1.73(s, 3H, CH₃)1.14-0.95(m, 1H)

(I -87) 17.12(bs, 1H, OH)7.95(s, 1H, COH)7.92(d, J=8.03Hz, 1H, ArH)7.08(d, J=8.03Hz, 1H, ArH)4.08(s, 3H, OCH₃)3.26(s, 3H, SO₂ CH₃)2.50(m, 1H)2.29(m, 1H) 1.72(m, 1H)1.68(s, 3H, CH₃)0.94(m, 1H)

(I-90) 7.67(m, 1H, ArH)6.82(m, 1H, ArH)3.90(s, 3H, OCH₃)3.41(s, 3H, OCH₃) 3.22(s, 3H, SO₂ CH₃)2.23(s, 3H, ArCH₃)1.83(m, 1H)1.59(m, 1H)1.40(s, 3H, CH₃) 1.31(m, 1H)1.02(m, 1H)

(II-1) 17.50(s, 1H, OH)7.95(m, 1H, PyH)7.60(m, 1H, PyH)3.52, 3.38(m, 3H, OCH₃) 3.22(m, 3H, SO₂ CH₃)2.53(m, 3H, PyCH₃)2.22(m, 2H)1.60(m, 1H) 1.63, 1.50(3H, CH₃)1.16(m, 1H)

(II-2) 17.64, 16.70(1H, OH)7.95(m, 1H, PyH) 7.60(m, 1H, PyH) 3.33, 3.10(3H, OCH₃) 3.25(s, 3H, SO₂ CH₃)2.55(m, 3H, PyCH₃)2.20(m, 2H)1.63(m, 1H) 1.65, 1.39(3H, CH₃)0.80(m, 1H)

(II-27) 7.85, 7.80(d, 1H, ArH)6.99, 6.91(d, 1H, ArH)3.97, 3.95(s, 3H, ArOCH₃)3.53, 3.35(s, 3H, OCH₃)3.27, 3.25(s, 3H, SO₂ CH₃)2.26, 2.24(s, 3H, ArCH₃) 1.01, 0.85(t, CH₃)2.50-1.80(m, 1H)

(II-31) 7.83, 7.79(d, 1H, ArH)6.97, 6.92(d, 1H, ArH)3.96, 3.94(s, 3H, ArOCH₃)3.30-3.80(m, 2H)3.24(s, 3H, SO₂ CH₃)2.24, 2.22(s, 3H, ArCH₃)1.28, 1.12(m, 1H) 1.02, 0.89(t, 3H)

(II-32) 7.82, 7.80(d, 1H, ArH)6.96, 6.91(d, 1H, ArH)3.97(s, 3H, ArOCH₃) 3.32, 2.85(m, 2H)3.26, 3.24(s, 3H, SO₂ CH₃)2.26, 2.24(s, 3H, ArCH₃)2.30-0.70(m, 8H)1.12, 0.95(t, 3H)10.88(t, 3H)

The compounds according to the present invention represented by the general formula I! and the salts thereof provide an high herbicidal activity in fields of upland crops by either method of soil application or foliar application. For example, the compounds according to the present invention show to have an excellent herbicidal activity by means of foliar application to hazardous weeds in upland crop fields, such as crabgrass, foxtails, velvet leaf, pigweed, cocklebur etc., and some of such compounds show to have selectivity in their herbicidal activity between weeds and crops, which are not toxic to crops, such as maize, cereals, soybeans, cotton plant, etc. In particular, the compounds according to the present invention have an excellent herbicidal activity against hazardous weeds , such as foxtails, pigweed and cocklebur in maize cultivation so that the compounds are very uszful as the active one of herbicide for weed control in maize fields.

Further, in the compounds of the present invention, compounds which have a growth-regulating activity against useful plants, such as agricultural crops, ornamental plants and fruit trees, are contained as well.

Moreover, the compounds of the present invention show to have an excellent herbicidal activity against weeds grown in paddy rice fields, such as barnyardgrass, umbrella plants (Cyperus difformis and Scirpus juncoides) and water plantains, and some of the compounds have selectivity in their herbicidal activity between such weeds and rice plants.

Furthermore, the compounds according to the present invention can be also applied for weed control in orchards, lawns, areas along the side of railways, vacant lands, etc.

The compounds according to the present invention are low toxic to both fishes and homeothermal animals, and are therefore considered as highly safe chemicals.

Herbicides!

The herbicide according to the present invention comprises one or more of the compounds according to the present invention as the active ingredient(s). At a practical application of the inventive compounds, such compounds can be applied without combining with other elements. Alternatively, such inventive compounds can be also prepared into any of formulation types to be normally employed as plant protection chemicals, such as wettable powder, granules, dust, emulsifiable concentrate, water soluble powder, suspension and flowable formulations. As an additive or a filler used for such formulations, vegetable-origin powder, such as soybean powder and wheat flour, mineral fine powder, such as diatomaceous earth, apatite, gypsum, talc, bentonite, pyrophyllite and clay, and organic or inorganic materials, such as sodium benzoate, urea and Glauber's salt, can be used for a solid-type formulation. In case liquid-type formulations are required, a petroleum fraction, such as kerosine, xylene and solvent naphtha, cyclohexane, cyclohexanone, dimethyl formamide, dimethyl sulfoxide, alcohol, acetone, methylisobutyl ketone, mineral oil, vegetable oil, water, etc. can be used as a solvent. In order to assure uniform and stable physicochemical properties for such formulations, a surface active agent may be used, if appropriate.

The content or the concentration of active ingredient contained in the herbicide according to the present invention can differ to various ranges depending upon formulation types as described above. For example, such content can be in a range of from 5 to 90%, and preferably of from 10 to 85%, for a wettable powder formulation; from 3 to 70%, and preferably of from 5 to 30%, for an emulsifiable concentrate formulation; and from 0.01 to 30%, and preferably of from 0.05 to 10%, for a granular formulation.

The wettable powder and the emulsifiable concentrate obtained as described above can be applied in a form of suspension or emulsion after diluting such formulations with appropriate volume of water. The granules obtained as described above can be applied to and/or incorporated into soil without dilution prior to or after germination of weeds. For practical application of the herbicide according to the present invention, a formulation wherein the compound of the present invention is contained as the active ingredient is applied at an appropriate dose more than 0.1 g/10 a based said active ingredient.

The herbicide according to the present invention can be also used by a mixing with any of other known fungicides, insecticides, acaricides, herbicides, plant growth regulators, etc. In particular, it is possible to reduce the dose of the active ingredient in the inventive herbicide in practical uses owing to a mixing with other herbicide. In this case, such mixing may provide an effect not only to reduce labours required for weeding but also to give higher herbicidal performance because of a synergistic action brought by both herbicides mixed together. It is also possible to make combinations with the inventive herbicidal compound and a plurality of other known herbicides.

For the examples of herbicides to be preferably associated with the inventive herbicide, carbamate herbicides, such as benthiocarb, molinate and dimepiperate, thiocarbamate herbicides, acid amide herbicides, such as butachlor, pretilachlor and mefenacet, diphenyl ether herbicides, such as chlomethoxynil and bifenox, triazine herbicides, such as atrazine and cyanazine, sulfonylurea herbicides, such as chlorsulfuron and sulfometuron-methyl, phenoxyalkanebarboxylic acid herbicides, such as MCP, and MCPB, phenoxyphenoxypropionic acid herbicides such as diclofop-methyl, pyridyloxyphenoxypropionic acid herbicides such as fluazifop-butyl, dinitroaniline herbicides, such as trifluralin and pendimethalin, urea herbicides, such as linuron and diuron, benzoylaminopropionic acid herbicides, such as benzoylprop ethyl and furanprop ethyl, imidazolinone herbicides such as imazaquin, and others, such as piperophos, dymron, bentazone, difenzoquat, naproanilide, etobenzanid, triazofenamide, quinclorac, and cyclohexanedione herticides. such as sethoxydim and clethodim, can be given. In addition, a vegetable oil and an oil concentrate may be added to a combination consisting of the inventive herbicide and one or more of the herbicides exemplified above.

Herbicides!

Now, examples for manufacturing formulations suitable for the herbicide according to present invention are given hereinbelow. However, a compound to be used as an active component, types of additives and additional portions of the additives to use shall be modified in wide ranges and shall not be limited to the ones specified in the examples described hereinbelow. The part described in the following Examples represent parts by weight based on the weight of the formulation.

(EXAMPLE 6)

Wettable Powder

    ______________________________________                                         The inventive compound                                                                           20         parts                                             White carbon      20         parts                                             Diatomaceous earth                                                                               52         parts                                             Sodium alkylsulfate                                                                              8          parts                                             ______________________________________                                    

All materials are uniformly mixed and grinded into fine powders to obtain a wettable powder formulation comprising an active ingredient at a content of 20%.

(EXAMPLE 7)

Emulsifiable Concentrate

    ______________________________________                                         The inventive compound                                                                             20        parts                                            Xylene              55        parts                                            Dimethylformamide   15        parts                                            Polyoxyethylene phenyl ether                                                                       10        parts                                            ______________________________________                                    

All materials are mixed and dissolved to obtain an emulsifiable concentrate formulation comprising an active ingredient at a content of 20%.

(EXAMPLE 8)

Granules

    ______________________________________                                         The inventive compound                                                                           5          parts                                             Talc              40         parts                                             Clay              38         parts                                             Bentonite         10         parts                                             Sodium alkylsulfate                                                                              7          parts                                             ______________________________________                                    

All materials are uniformly mixed, grinded to fine powders and then granulated into granules having a diameter of from 0.5 to 1.0 mm to obtain a granular formulation comprising an active ingredient at a content of 5%.

A test example carried out to show a herbicidal activity of the herbicides according to the present invention are now described hereinbelow.

However, the herbicidal activity as described hereinbelow is evaluated pursuant to the following criterion, and therefore, the herbicidal activity is expressed as an index for killed-weeds.

    ______________________________________                                         Criterion for assessment                                                       % of weeds killed                                                                            Index for killed-weeds                                           ______________________________________                                         0%            0                                                                20-29%        2                                                                40-49%        4                                                                60-69%        6                                                                80-89%        8                                                                100%          10                                                               ______________________________________                                    

Indexes 1, 3, 5, 7 and 9 represent an intermediate activity between 0 and 2, 2 and 4, 4 and 6, 6 and 8, and 8 and 10, respectively.

% of Weeds Killed (Weight of fresh weeds growing over the ground in non-treated plot-Weight of fresh weeds growing over the ground in a treated-plot)÷(Weight of fresh weeds growing over the ground in non-treated plot)!×100

(Test Example 1) Foliar application

In a 200 cm² planting pot filled with soil beforehand, seeds of giant foxtail, pigweed, cocklebur and maize are respectively planted, and the seeds are then covered with a slight amount of soil to grow in a greenhouse. When each of such weeds and maize have grown to a height of 5 to 10 cm and at 20 cm height, respectively, a water emulsion prepared with an emulsifiable concentrate prepared for the test compound was applied by using a small sprayer to the leaves of the weeds and maize at a dose rate specified in Table 5 and with a spray volume rate of 100 liters/10 a. Three weeks later, the herbicidal performance of the compounds were respectively assessed pursuant o the criterion as described above, and the results are presented in Tables 3 and 4 described below.

                  TABLE 5                                                          ______________________________________                                         Compound                                                                               Dose    Index for Killed-Weeds                                         No.     g/10a   Giant foxtail                                                                            Pigweed                                                                               Cocklebur                                                                              Maize                                 ______________________________________                                         I-2     12.5    10        10     10      3                                     I-3     12.5    10        10     10      0                                     I-4     12.5    10        10     10      4                                     I-8     12.5    10        10     10      0                                     I-13    12.5    10        10     10      0                                     I-14    12.5    10        10     10      0                                     I-16    12.5    10        10     10      0                                     I-17    12.5    10        10     10      0                                     I-18    12.5    10        10     10      0                                     I-19    12.5    10        10     10      0                                     I-20    12.5    10        10     10      0                                     1-22    12.5    10        10     10      0                                     I-24    12.5    10        10     10      0                                     I-25    12.5    10        10      8      0                                     I-26    12.5    10        10      9      0                                     I-27    12.5    10        10     10      0                                     I-28    12.5    10        10     10      0                                     I-29    12.5    10        10     10      0                                     I-30    12.5    10        10     10      0                                     I-31    12.5    10        10     10      0                                     I-32    12.5    10        10     10      0                                     I-33    12.5    10        10     10      0                                     I-34    12.5    10        10     10      0                                     I-36    12.5    10         9      9      0                                     I-37    12.5    10        10     10      0                                     I-38    12.5    10        10     10      0                                     1-40    12.5    10        10     10      0                                     I-41    12.5    10        10     10      0                                     I-42    12.5    10        10     10      0                                     I-44    12.5    10         9      9      3                                     I-46    12.5    10         9     10      0                                     I-48    12.5    10        10     10      0                                     I-53    6.25    10         7      9      0                                     I-55    12.5    10         9      9      0                                     I-59    12.5     9         9      9      0                                     I-60    12.5     9         8      9      0                                     1-62    12.5    10        10      9      0                                     I-64    6.25    10         9      9      0                                     I-65    6.25    10        10      9      0                                     I-69    12.5     9        10      9      0                                     I-70    12.5    10        10      8      0                                     I-74    12.5     9        10     10      4                                     I-77    12.5    10         9      9      0                                     I-81    12.5    10        10     10      2                                     I-83    12.5    10        10     10      2                                     I-90    12.5    10        10     10      0                                     II-27   12.5    10         9      8      0                                     II-31   12.5    10        10      8      0                                     IV-2    12.5    10        10     10      0                                     Compound                                                                               12.5     5        10     10      0                                     ______________________________________                                    

Compound A (For comparison) ##STR26## Industrial Use of the Invention

As explained above, substituted-bicycloheptanedione derivatives and the salts thereof according to the present invention are hating an excellent herbicidal activity, and herbicides comprising tie said compounds and the salts as the active component(s) are considered as an useful herbicide. 

What is claimed is:
 1. Substituted bicycloheptanedione derivatives represented by the formula I!; ##STR27## wherein R represents a C₁ -C₄ alkyl, R¹ represents hydrogen, a C₁ -C₁₀ alkyl, a C₂ -C₄ alkenyl, a C₂ -C₄ alkynyl, an aralkyl, a C₂ -C₄ haloalkynyl, a C₁ -C₄ alkoxy C₁ -C₄ alkyl, a C₁ -C₄ haloalkyl, a C₂ -C₄ haloalkenyl, a hydroxy C₁ -C₄ alkyl, a --A--C₃ -C₆ cycloalkyl, --A--C(O)r, --A--CH₂ CN or phenyl, A represents a single bond or C₁ -C₄ alkylene, r represents hydrogen, a C₁ -C₄ alkyl, a C₁ -C₄ alkoxy or phenyl,and R² represents optionally substituted phenyl or optionally substituted pyridyl, and the salts thereof.
 2. (Amended) Substituted bicycloheptanedione derivatives represented by the formula (II): ##STR28## wherein R represents a C₁ -C₄ alkyl, R¹ represents hydrogen, a C₁ -C₁₀ alkyl, a C₂ -C₄ alkenyl, a C₂ -C₄ alkynyl, an aralkyl, a C₂ -C₄ haloalkynyl, a C₁ -C4 alkoxy C₁ -C₄ alkyl, a C₁ -C₄ haloalkyl, a C₂ -C₄ haloalkenyl, a hydroxy C₁ -C₄ alkyl, a --A--C₃ -C₆ cycloalkyl, --A--C(O)r, --A--CH₂ CN or phenyl, A represents a single bond or C₁ -C₄ alkylene, r represents hydrogen, a C₁ -C₄ alkyl, a C₁ -C₄ alkoxy or phenyl, and R¹⁰ represents a C₁ -C₄ alkyl, an aralkyl or acetyl.
 3. A herbicidal composition comprising a herbicidally effective amount of a substituted bicycloheptanedione derivative according to claim
 1. 4. Substituted bicycloheptanedione derivatives represented by the formula (I): ##STR29## wherein R represents a C₁ -C₄ alkyl, R¹ represents hydrogen, a C₁ -C₄ alkyl, a C₂ -C₄ alkenyl, a C₂ -C₄ alkynyl, a C₁ -C₄ alkoxy C₁ -C₄ alkyl, a C₁ -C₄ haloalkyl, a C₂ -C₄ haloalkenyl, a C₁ -C₄ alkylcarbonyl-C₁ -C₄ alkyl, a C₁ -C₄ alkylcarbonyl, a C₁ -C₄ alkoxycarbonyl-C₁ -C₄ alkyl, a C₁ -C₄ alkoxycarbonyl, a benzoyl, a benzoyl-C₁ -C₄ alkyl or formyl, R² is a phenyl which is substituted by halogen, C₁ -C₅ alkyl, C₁ -C₄ haloalkyl, C₁ -C₄ alkoxy, C₁ -C₄ haloalkoxy, C₂ -C₄ alkenyloxy, C₂ -C₄ alkynyloxy, C₂ -C₄ haloalkenyloxy, C₁ -C₄ alkoxy-C₁ -C₄ alkyl, C₁ -C₄ alkoxy-C₁ -C₄ alkoxy, nitro, C₁ -C₄ alkoxycarbonyl, C₁ -C₄ alkylthio, C₁ -C₄ alkylsulfinyl, C₁ -C₄ alkylsulfonyl, C₂ -C₄ alkenyl, C₂ -C₄ haloalkenyl, C₁ -C₄ alkylthio-C₁ -C₄ alkyl, C₁ -C₄ alkylsulfonyl-C₁ -C₄ alkyl, C₁ -C₄ -alkylsulfinyl-C₁ -C₄ alkyl, C₁ -C₄ dialkylaminosulfonyl, carbamoyl, C₁ -C₄ alkylcarbamoyl, C₁ -C₄ dialkylcarbamoyl, carboxy, C₁ -C₄ alkylcarbonyl, hydroxy, cyano, C₂ -C₄ alkenylthio, C₂ -C₄ alkenylsulfinyl, C₂ -C₄ alkenylsulfonyl, C₂ -C₄ alkynylthio, C₂ -C₄ alkynylsulfinyl, C₂ -C₄ alkynylsulfonyl, C₁ -C₄ haloalkylthio, C₁ -C₄ haloalkylsulfinyl, C₁ -C₄ haloalkylsulfonyl, amino, C₁ -C₄ alkylamino, C₁ -C₄ dialkylamino, C₁ -C₄ alkoxy-C₁ -C₄ alkylamino, N-C₁ -C₄ alkyl-N-C₁ -C₄ alkoxy-C₁ -C₄ alkylamino, C₁ -C₄ alkoxyamino, N-C₁ -C₄ alkyl-N-C₁ -C₄ alkoxyamino, C₁ -C₄ alkylcarbonylamino, N-C₁ -C₄ alkyl-N-C₁ -C₄ alkylcarbonylamino, C₁ -C₄ alkoxycarbonylamino, N-C₁ -alkyl-N-C₁ -C₄ alkoxycarbonylamino, C₁ -C₄ alkylsulfonylamino, N-C₁ -C₄ alkyl-N-C₁ -C₄ alkylsulfonylamino, aminosulfonyl, C₁ -C₄ alkylaminosulfonyl, C₁ -C₄ alkylthio-C₁ -C₄ alkoxy, C₁ -C₄ alkylsulfinyl-C₁ -C₄ alkoxy or C₁ -C₄ alkylsulfonyl-C₁ -C₄ alkoxy.
 5. A herbicidal composition comprising a herbicidally effective amount of a substituted bicycloheptanedione derivative according to claim
 4. 6. A substituted bicycloheptanedione derivative of claim 4 having the formula: ##STR30## wherein R is Cl or CH₃.
 7. A substituted bicycloheptanedione derivative of claim 4 having the formula: ##STR31## wherein R is Cl or CH₃.
 8. A substituted bicycloheptanedione derivative of claim 4 having the formula: ##STR32## wherein R is Br or OCHF₂.
 9. A substituted bicycloheptanedione derivative of claim 4 having the formula: ##STR33##
 10. A substituted bicycloheptanedione derivative of claim 4 having the formula: ##STR34## wherein R is C₂ H₅, nC₃ H₇ ^(n), iC₃ H₇, CH₂ C=CH or CHO.
 11. A substituted bicycloheptanedione derivative of claim 4 having the formula: ##STR35## wherein R is C₂ H₅, CH₂ CF₃ or C₃ H₇ ¹. 